… study (Sapphire) with the idea of validating the performance of the newly discovered cell cycle
… adjudicated 420 critically ill patients to a panel of nephrologist that blindly determine if the …

… validate prior observations on the relationship between measures of these biomarkers
together with clinical … injury using clinical adjudication. Am J Respir Crit Care Med 2014;189:932–…

… In this secondary analysis of the Sapphire study, we examined biomarkers of cell cycle arrest
… Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. …

… Although the overall findings are consistent with recent studies, our thresholds do need
further validation. The main strength of the study is the clinical design. The restricted inclusion …

… The recent discovery of cell cycle arrest biomarkers, tissue inhibitor of metalloproteinases
(… ), has led to a newly available clinical test for acute kidney injury. The performance of these …

… validated models using clinical variables alone for AKI in general hospitalized populations,
and all had limitations in predictive performance for use in … performed blinded adjudication of …

… or their equivalents such as acute kidney injury, outcome and Cell cycle arrest biomarker. …
Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. …

… Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical
adjudication. Am J Respir Crit Care Med 2014;189:932–9. https://doi.org/10.1164/rccm.201401-…

… The cell cycle arrest markers tissue inhibitor … ) have been identified as potential
biomarkers of acute kidney injury (AKI) in … validated the cutoffs of 0.3 and 2.0 for moderate-to-severe …

… ) were validated for development of AKI well ahead of clinical … that supports the use of
cell-cycle arrest biomarkers for risk … point was determined by clinical adjudication by AKI experts …