AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures

JW Eom, JM Lee, JY Koh, YH Kim - Molecular Brain, 2016 - Springer
… Caspase-3 activation was also reduced by Compound C in zinc-induced neuronal cell death
that zinc-induced neuronal death shows apoptotic and necrotic aspects in cortical cultures […

The important role of zinc in neurological diseases

Z Li, Y Liu, R Wei, VW Yong, M Xue - Biomolecules, 2022 - mdpi.com
neuronal damage and improvement in neurological function [82]. In MCAO rats, zinc-induced
role of zinc in neuronal function, damage, repair, apoptosis, and necrosis. Excessive zinc is …

Mechanism of zinc excitotoxicity: a focus on AMPK

YH Kim, JW Eom, JY Koh - Frontiers in Neuroscience, 2020 - frontiersin.org
neuronal death pathways, we tried to see the neuroprotection against zinc excitotoxicity,
calcium-overload excitotoxicity, oxidative damage, and apoptosis. … , zinc-induced excitotoxicity is …

Zinc homeostasis: an emerging therapeutic target for neuroinflammation related diseases

S Liu, N Wang, Y Long, Z Wu, S Zhou - Biomolecules, 2023 - mdpi.com
… by ZnT1, while other zinc transporters mediate the transport of Zn 2+ … Therefore, ZnG inhibited
neuronal apoptosis in the injured … discharges and mediated neuronal death. Treatment of …

Zinc causes the death of hypoxic astrocytes by inducing ROS production through mitochondria dysfunction

R Pan, KJ Liu, Z Qi - Biophysics Reports, 2019 - Springer
neuronal death rate was much higher than astrocytic death … decreased zinc-induced hypoxic
primary astrocytic death … had much lesser effect in preventing zinc-induced cell death (Fig. 4)…

Dopamine Activates the D1R-Zn2+ Signaling Pathway to Trigger Inflammatory Response in Primary-Cultured Rat Embryonic Cortical Neurons

HC Tseng, CY Pan - Cellular and Molecular Neurobiology, 2023 - Springer
… and cell death in primary cultured rat embryonic neurons. … leading to cell death in cultured
cortical neurons. Pretreating … with IL-1β protected against dopamine-induced neuron death

Zinc in the brain: friend or foe?

S Choi, DK Hong, BY Choi, SW Suh - International Journal of Molecular …, 2020 - mdpi.com
… An accumulation of zinc can lead to neuronal death following … The mediation of cell division
by growth factors requires the … mechanisms of zinc-induced neuronal cell death is known as …

Cellular toxicity of zinc can be attenuated by sodium hydrogen sulfide in neuronal SH-SY5Y cell

SR Lee - Molecular & Cellular Toxicology, 2018 - Springer
… be an important mediator in a myriad of neural functions, including … Hydrogen sulfide
ameliorates zinc-induced cell death in … Zinc-induced cortical neuronal death: contribution of …

TPEN, a Specific Zn2+ Chelator, Inhibits Sodium Dithionite and Glucose Deprivation (SDGD)-Induced Neuronal Death by Modulating Apoptosis, Glutamate Signaling, and Voltage-Gated K …

F Zhang, X Ma, Y Wang, C He, K Tian, H Wang… - Cellular and molecular …, 2017 - Springer
… increases in cell death, apoptosis, neuronal glutamate release … channel activity in primary
cultured neurons exposed to SDGD. … of Zn 2+ in mediating ischemic injury, future investigations …

The function and regulation of zinc in the brain

RF Krall, T Tzounopoulos, E Aizenman - Neuroscience, 2021 - Elsevier
… Top panel shows a micrograph depicting rat cortical neurons … (CTZ) prevents zinc-induced
potentiation of AMPARs in both … on GluK3 that specifically mediate zinc potentiation, aspartate …