[HTML][HTML] Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates

A Zellner, SA Müller, B Lindner, N Beaufort… - Acta neuropathologica …, 2022 - Springer
… MS1 spectra were acquired at a resolution of 120,000, a scan … the proteins overlapping
between CAA type 1 and CADASIL … quality control across multiple species including removal of …

Vascular Disorders: Angiopathies

S Weis, M Sonnberger, A Dunzinger… - Imaging Brain Diseases …, 2019 - Springer
Cerebral amyloid angiopathy (CAA) is a heterogeneous disease … Treatment includes surgical
removal of hemorrhage while … patients seem to be within the normal CADASIL spectrum. …

Clinical and genetic aspects of CADASIL

T Mizuno, I Mizuta, A Watanabe-Hosomi… - Frontiers in aging …, 2020 - frontiersin.org
… distribution of GOM and N3ECD protein in the microvasculature of brain gray matter and WM…
They also suggest a broad disease spectrum involving EGFr 7–34, from a mild phenotype to …

Current management and therapeutic strategies for cerebral amyloid angiopathy

Y Inoue, Y Ando, Y Misumi, M Ueda - International journal of molecular …, 2021 - mdpi.com
… In addition to its insulin-degrading effects, IDE degrades Aβ and promotes Aβ removal, as
in … , N.; Younkin, SG Amyloid β protein (Aβ) in Alzheimer’s disease brain. Biochemical and …

CADASIL brain vessels show a HTRA1 loss-of-function profile

A Zellner, E Scharrer, T Arzberger, C Oka… - Acta …, 2018 - Springer
… Full MS spectra were acquired at a resolution of 70,000 and … This procedure resulted in
efficient removal of non-vascular … leptomeningeal arteries of cerebral amyloid angiopathy (CAA) …

[HTML][HTML] The pericyte: A critical cell in the pathogenesis of CADASIL

MM Ruchoux, RN Kalaria, GC Román - Cerebral Circulation-Cognition and …, 2021 - Elsevier
… Although various proteins including inflammatory-immune system markers are evident in …
Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study …

Emerging concepts in sporadic cerebral amyloid angiopathy

A Charidimou, G Boulouis, ME Gurol, C Ayata… - Brain, 2017 - academic.oup.com
… , cerebral amyloid angiopathy appears to be in part a protein elimination failure angiopathy
and … ’ groups together a spectrum of sporadic non-amyloid small vessel disease pathologies …

[HTML][HTML] Notch3 signaling and aggregation as targets for the treatment of CADASIL and other NOTCH3-associated small-vessel diseases

D Schoemaker, JF Arboleda-Velasquez - The American Journal of …, 2021 - Elsevier
… Abnormal protein aggregation has been described as a key … cerebral amyloid angiopathy.
It has therefore been suggested that CADASIL falls within the spectrum of protein elimination

APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL

B Gesierich, C Opherk, J Rosand… - Journal of Cerebral …, 2016 - journals.sagepub.com
… APOE in Alzheimer’s disease and cerebral amyloid angiopathy, which are both common in
… in CADASIL, APOE ɛ2 may be associated with impaired drainage of other proteins leading to …

Proteostasis in cerebral small vessel disease

C Haffner - Frontiers in neuroscience, 2019 - frontiersin.org
… proteotoxicity to protein degradation and aggregate removal. … Cerebral amyloid angiopathy
is a brain condition frequently … in CADASIL and CAA, they yielded a shared set of proteins