Electrical stimulation of denervated rat skeletal muscle retards capillary and muscle loss in early stages of disuse atrophy

K Nakagawa, H Tamaki, K Hayao… - BioMed Research …, 2017 - Wiley Online Library
… immunoreactivity, fiber atrophy, and capillary regression in denervated muscleMMP-2
immunoreactivity following DN and that daily low-frequency ES treatment on denervated muscle

Intermittent stretching induces fibrosis in denervated rat muscle

FM Faturi, RC Franco, D Gigo‐Benato, AC Turi… - Muscle & …, 2016 - Wiley Online Library
… Regarding gene expression of MMP-2, MMP-9, and TIMP-1, we found that MMP-2 was
upregulated in the D 15d group compared with the others (P < 0.05; Fig. 5A); for …

Matrix Metalloproteinase-9 is involved in the fibrotic process in denervated muscles after sciatic nerve trauma and recovery

O Goncharuk, S Savosko, A Tykhomyrov… - … Surgery Part A …, 2023 - thieme-connect.com
MMP-2 and MMP-9 are found in neuromuscular junctions, Schwann's cells, and perineurium
of the denervated muscle … [15] Collectively, these data suggest that ММР-2 and MMP-9 are …

LLLT actives MMP-2 and increases muscle mechanical resistance after nerve sciatic rat regeneration

RAC Andraus, LP Maia, AD de Souza Lino… - Lasers in medical …, 2017 - Springer
… the hypothesis that the denervated muscle response to high … nerve would involve the activation
of MMP-2. The aim of the … J/cm 2 ), moderate (70 J/cm 2 ), and high (140 and 280 J/cm 2 ) …

Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-β

DL Rebolledo, D González, J Faundez-Contreras… - Matrix Biology, 2019 - Elsevier
… To evaluate if CTGF has a role in regulating the amount of FAPs, we used total homogenates
from control and denervated muscles for 2 weeks and evaluated PDGFR-α and Tcf4 levels. …

Expression and effects of matrix metalloproteinase 2 and 9 and tissue inhibitor of metalloproteinase 1 and 2 in the denervated skeletal muscle of rats

B Chen, J Liang, Z Chen - Chinese Journal of Tissue Engineering …, 2018 - cjter.com
… in the denervated skeletal muscle. There was a rapid increase of MMP-2 and TIMP-2 with
double peaks at the 3 and 56 days after modeling; at the 3 and 70 days, the expression of MMP

Electrical stimulation based on chronaxie increases fibrosis and modulates TWEAK/Fn14, TGF-β/myostatin, and MMP pathways in denervated muscles

CM Pinheiro-Dardis, TL Russo - American Journal of Physical …, 2017 - journals.lww.com
… applied to denervated muscles induced muscle fibrosis and … /myostatin pathway, and MMP
activity seem to be involved in … 2) gene expressions are increased in denervated muscles (…

Matrix metalloproteinases and tissue inhibitor of metalloproteinases in inflammation and fibrosis of skeletal muscles

HS Alameddine, JE Morgan - Journal of neuromuscular …, 2016 - content.iospress.com
… , are preserved during the denervation/reinnervation process [… accomplished by MMP-2,
MMP-9, MMP-10 and MMP-14 but … [110] and selective denervation of fast muscles in the SOD1 …

The matrix metalloproteinase and tissue inhibitors of metalloproteinase balance in physiological and pathological remodeling of skeletal muscles

HS Alameddine - Proteases in Physiology and Pathology, 2017 - Springer
muscle atrophy than MMP-9-deficient mice [93]. Upregulation of MMP-2 activity is reported in
denervated muscles … seems to be restricted to atrophic muscles because single or repetitive …

Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice

R Mukai, N Matsui, Y Fujikura, N Matsumoto… - The Journal of nutritional …, 2016 - Elsevier
… events during disuse muscle atrophy [5]. In fact, 8-hydroxy-2′-deoxyguanosine and proteins
conjugated with 4-hydroxy-2-noneral were identified in atrophied muscle of unloaded mice …