[HTML][HTML] A comprehensive assessment of phytochemicals from Phyla nodiflora (L.) Greene as a potential enzyme inhibitor, and their biological potential: An in-silico, in …

A Alafnan, MF Nadeem, SF Ahmad, M Sarfraz… - Arabian Journal of …, 2023 - Elsevier
… /g extract) enzyme inhibition activity. … enzymes was highlighted by molecular docking
studies. In sum, this research showed that the studied extracts were effective as enzyme inhibitors

A comprehensive guide for assessing covalent inhibition in enzymatic assays illustrated with kinetic simulations

E Mons, S Roet, RQ Kim, MPC Mulder - Current protocols, 2022 - Wiley Online Library
… the effects of in vitro enzyme activity assay conditions and inhibitor binding mode, thereby
… to assess the biochemical potency of (ir)reversible covalent enzyme inhibitors targeting a …

Prediction of severity of drug-drug interactions caused by enzyme inhibition and activation

A Dmitriev, D Filimonov, A Lagunin, D Karasev… - Molecules, 2019 - mdpi.com
inhibiting and/or inducing the metabolism or transporter-mediated disposition of the victim
drug. Accurate assessment … A comprehensive description of the methods for DDIs prediction is …

Neurotoxicity assessment of four different pesticides using in vitro enzymatic inhibition assays

C Martins-Gomes, TE Coutinho, TL Silva, T Andreani… - Toxics, 2022 - mdpi.com
… analyzed in this study that inhibited both enzymes, AChE and BChE. At 500 µM, IMZ inhibited
AChE activity by about 48%, being this the higher inhibition value obtained (Figure 3A). As …

Recent advances in enzyme inhibition based-electrochemical biosensors for pharmaceutical and environmental analysis

J Li, H Chang, N Zhang, Y He, D Zhang, B Liu, Y Fang - Talanta, 2023 - Elsevier
… and detection of enzymatic inhibitors owing to their low-cost, … a comprehensive overview
of the current status of enzyme … of DON and BER to inhibit AChE being assessed through the …

… of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on angiotensin-converting enzyme 2 levels: a comprehensive analysis based on …

G Kriszta, Z Kriszta, S Vancsa, PJ Hegyi… - Frontiers in …, 2021 - frontiersin.org
… Three studies assessed the influence of RAS inhibitors on ACE2 expression under
physiological conditions. Following 12-days long oral administration, lisinopril or losartan elevated …

[HTML][HTML] Human carboxylesterases: a comprehensive review

D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
… substrates have been recently developed for assessing the real activities of CES1 or …
inhibitors or inducers of CES have been identified with the specific intention of altering enzyme

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics

R Tyagi, MA Elfawal, SA Wildman, J Helander… - Scientific reports, 2019 - nature.com
… This work formed the basis of further exploration of putative CPT inhibitors repurposed for …
, requiring us to develop a comprehensive method for enzyme annotation, and generate …

Pesticide detection in vegetable crops using enzyme inhibition methods: a comprehensive review

H Bedair, HA Rady, AM Hussien, M Pandey… - Food Analytical …, 2022 - Springer
… Indeed, utilization of enzyme inhibition method in pesticide … on enzyme inhibition biosensors
for determining pesticides and highlights different biological sources of these enzymes. The …

Cytochrome P450 enzymes: a review on drug metabolizing enzyme inhibition studies in drug discovery and development

SN Rao Gajula, MS Pillai, G Samanthula, R Sonti - Bioanalysis, 2021 - Taylor & Francis
… and decision-making processes for assessing the drug–drug interaction risks by enzyme
While this may provide insight into the mechanism of inhibition, comprehensive matrix-based …