E Mons, S Roet, RQ Kim, MPC Mulder - Current protocols, 2022 - Wiley Online Library
… the effects of in vitro enzyme activity assay conditions and inhibitor binding mode, thereby … to assess the biochemical potency of (ir)reversible covalent enzymeinhibitors targeting a …
A Dmitriev, D Filimonov, A Lagunin, D Karasev… - Molecules, 2019 - mdpi.com
… inhibiting and/or inducing the metabolism or transporter-mediated disposition of the victim drug. Accurate assessment … A comprehensive description of the methods for DDIs prediction is …
… analyzed in this study that inhibited both enzymes, AChE and BChE. At 500 µM, IMZ inhibited AChE activity by about 48%, being this the higher inhibition value obtained (Figure 3A). As …
J Li, H Chang, N Zhang, Y He, D Zhang, B Liu, Y Fang - Talanta, 2023 - Elsevier
… and detection of enzymaticinhibitors owing to their low-cost, … a comprehensive overview of the current status of enzyme … of DON and BER to inhibit AChE being assessed through the …
G Kriszta, Z Kriszta, S Vancsa, PJ Hegyi… - Frontiers in …, 2021 - frontiersin.org
… Three studies assessed the influence of RAS inhibitors on ACE2 expression under physiological conditions. Following 12-days long oral administration, lisinopril or losartan elevated …
D Wang, L Zou, Q Jin, J Hou, G Ge, L Yang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
… substrates have been recently developed for assessing the real activities of CES1 or … inhibitors or inducers of CES have been identified with the specific intention of altering enzyme …
R Tyagi, MA Elfawal, SA Wildman, J Helander… - Scientific reports, 2019 - nature.com
… This work formed the basis of further exploration of putative CPT inhibitors repurposed for … , requiring us to develop a comprehensive method for enzyme annotation, and generate …
… Indeed, utilization of enzymeinhibition method in pesticide … on enzymeinhibition biosensors for determining pesticides and highlights different biological sources of these enzymes. The …
… and decision-making processes for assessing the drug–drug interaction risks by enzyme … While this may provide insight into the mechanism of inhibition, comprehensive matrix-based …