Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

E Swissa, Y Serlin, U Vazana, O Prager, A Friedman - Epilepsy & Behavior, 2019 - Elsevier
… , neuroinflammation, increasing neural excitability, reduction of seizure threshold,
excitatory synaptogenesis, impaired plasticity, and epileptogenesis. A key signaling pathway …

Imaging blood–brain barrier dysfunction as a biomarker for epileptogenesis

G Bar-Klein, S Lublinsky, L Kamintsky, I Noyman… - Brain, 2017 - academic.oup.com
… confirm blood–brain barrier dysfunction and neuroinflammation. … Our results show that early
blood–brain barrier pathology in … We suggest quantitative assessment of blood–brain barrier

Epileptiform activity and spreading depolarization in the blood–brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition …

K Lippmann, L Kamintsky, SY Kim… - Journal of Cerebral …, 2017 - journals.sagepub.com
… peri-ischemic blood–brain barrier dysfunction that included the … We conclude that blood-brain
barrier dysfunction in the peri-… , reduced inhibition and excitatory synaptogenesis 55 ; (3) …

Structural, molecular, and functional alterations of the blood-brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both?

W Löscher, A Friedman - International journal of molecular sciences, 2020 - mdpi.com
… in brain glutamate levels may lead to barrier dysfunction [21,36]. A … , contributing to barrier
dysfunction [37]. MMPs likely affect … further associated with synaptogenesis and neuroplasticity …

Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice

H Son, S Kim, D Jung, JH Baek, DH Lee, GS Roh… - Scientific reports, 2019 - nature.com
… Specifically, most excitatory synapses in the rodent brain are … roles of astrocytes in excitatory
synapse formation 5 . … , contacting the blood-brain barrier, and ensheathing neuronal …

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration

CM Henstridge, M Tzioras… - Frontiers in cellular …, 2019 - frontiersin.org
… synaptic dysfunction. Here, we review the recent literature on the contribution of glia to
excitatory/inhibitory imbalance, in the context of the most common neurodegenerative disorders. …

Synaptic elimination in neurological disorders

PL Cardozo, I de Lima, E Maciel… - Current …, 2019 - ingentaconnect.com
… via processes termed synaptogenesis and synaptic pruning, … , associated with blood-brain
barrier disruption, leading to massive in… While SPARCL1 promotes the formation of excitatory

Astrocyte-derived paracrine signals: relevance for neurogenic niche regulation and blood–brain barrier integrity

SF Spampinato, V Bortolotto, PL Canonico… - Frontiers in …, 2019 - frontiersin.org
… regulation has been associated with several CNS disorders. In agreement with these findings…
often associated with CNS remodeling and synaptogenesis. Some ECM proteins play also …

Blood-brain barrier-supported neurogenesis in healthy and diseased brain

EA Pozhilenkova, OL Lopatina, YK Komleva… - Reviews in the …, 2017 - degruyter.com
… and angiogenesis supported by specific properties of cerebral microvessel endothelial
cells contributing to establishment of partially compromised blood-brain barrier (BBB) for the …

Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
… well as blood-brain barrier dysfunction and dysregulation of blood flow. Since dysfunction of
… (459), and (5) induce excitatory, but not inhibitory synaptogenesis, contributing to potential …