Molecular mechanisms and signaling pathways involved in immunopathological events of COVID-19

AA Peyvandi, S Niknazar, F Zare Mehrjerdi… - Physiology and …, 2021 - ppj.phypha.ir
Cytokine storms are the main reason of COVID-19-related serious illness and death. The
most significant cause of cytokine storms can be the antibody-dependent enhancement. mTOR …

Cytokine storm in COVID-19 and the treatment simulacrum

A Karimi, SMR Hashemian - Biomedical and Biotechnology …, 2020 - journals.lww.com
mechanism of this ARDS in COVID-19 pneumonia is not known completely. There are ongoing
studies, but the term “cytokine storm” … and cellular pathways of cytokine storms and also …

Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

JLB Simões, HF Basso, GC Kosvoski, J Gavioli… - International …, 2021 - Elsevier
… trigger the so-called “cytokine storm”. This process generates … of COVID-19 is a cytokine
storm, one of which is responsible for … The cytokine storm mechanism during a viral infection is …

[HTML][HTML] Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19

FH Pottoo, T Abu-Izneid, AM Ibrahim, MN Javed… - Saudi pharmaceutical …, 2021 - Elsevier
… of “immunocytokines” resulting in cytokine storm (CS); … cytokine storm are now being
considered as a new paradigm shift in the clinical management of SARS-CoV-2. Tocilizumab (IL-6

Immunopathology and immunosenescence, the immunological key words of severe COVID-19. Is there a role for stem cell transplantation?

ME Ligotti, F Pojero, G Accardi, A Aiello… - Frontiers in Cell and …, 2021 - frontiersin.org
… However, which immunopathogenic status precedes this “cytokine storm” and why the male
older population is more severely affected, are currently unanswered questions. The aging …

COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?

A Maccio, S Oppi, C Madeddu - Journal of Ovarian Research, 2021 - Springer
… similarities between the cytokine storm of COVID 19 … IL-6 in immunopathology associated
to ovarian cancer and COVID-19. IL-6 is one of the key cytokines driving the immunopathology

Immunotherapy summary for cytokine storm in COVID-19

Y Li, W Zhao, J Liu, Z Chen, Q Lv… - Frontiers in Pharmacology, 2021 - frontiersin.org
… not yet sufficient to alleviate the cytokine storm (CS) and systemic inflammatory response
syndrome. How to neutralize the cytokine storm and inhibit excessive immune cell activation …

COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options

LE van Eijk, M Binkhorst, AR Bourgonje… - The Journal of …, 2021 - Wiley Online Library
… A bulk of cytokines is induced upon SARS-CoV-2 infection, most of which contribute to
hyperinflammation as constituents of the ‘cytokine storm’ in severe disease (eg IL-6, TNF-α, IL-1β, …

Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features

F Rommasi, MJ Nasiri, M Mirsaeidi - Molecular and cellular biochemistry, 2022 - Springer
… ' possible mechanisms of action. These drugs' mechanism of action generally includes
suppressing or modulating the immune system, preventing the development of cytokine storm via …

[PDF][PDF] Cytokine storm syndrome in COVID-19: diagnosis and management strategies

S Maggo, P Dhull, AP Dubey, D Brashier… - Int J Health Sci …, 2020 - researchgate.net
… to severe is immune dysfunction and cytokine dysregulation resulting in what is called as
cytokine storm syndrome”. It is prudent to diagnose cytokine storm early in the course of …