Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease

Q Zhang, C Ma, M Gearing, PG Wang, LS Chin… - Acta neuropathologica …, 2018 - Springer
… of disease-associated proteome changes in human frontal cortex of sporadic AD patients
using an integrated approach that combines mass spectrometry-based quantitative proteomics, …

[HTML][HTML] Integrated proteomics and metabolomics analysis reveals hubs protein and network alterations in myasthenia gravis

T Tong, J Zhang, L Jia, P Liang, N Wang - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
… , our integrated proteomics and metabolomics analysis supply a systems-level view of proteome
… -associated protein network alterations involved. The identified co-expressed modules …

Signaling pathway network alterations in human ovarian cancers identified with quantitative mitochondrial proteomics

N Li, X Zhan - Epma Journal, 2019 - Springer
… -based molecular network studies in OCs from multiparameter systematic opinion and
emphasize the importance of OC multiomics such as integrating proteomics and transcriptomics in …

Integrative proteomics and phosphoproteomics in pulmonary arterial hypertension

W Xu, SAA Comhair, R Chen, B Hu, Y Hou, Y Zhou… - Scientific Reports, 2019 - nature.com
… To build a comprehensive human interactome network, we integrated data from a total of
18 differential bioinformatics databases with multiple experimental evidences. Specifically, we …

Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer

TQ Gong, YZ Jiang, C Shao, WT Peng, MW Liu, DQ Li… - Cell reports, 2022 - cell.com
… We report a comprehensive proteomic study of a 90-case cohort of paired samples of
triple-… Four integrative subtypes (iP-1–4) are stratified on the basis of global proteome and …

Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation

H Tan, K Yang, Y Li, TI Shaw, Y Wang, DB Blanco… - Immunity, 2017 - cell.com
… T cell receptors activated the T cell proteome and phosphoproteome … proteomics profiling,
integrative network analysis, and functional studies define landscapes of the T cell proteome

Personalized integrated network modeling of the cancer proteome atlas

MJ Ha, S Banerjee, R Akbani, H Liang, GB Mills… - Scientific reports, 2018 - nature.com
… We aimed to estimate integrated cancer-specific networks using Bayesian regression
methods on each of the proteins with other molecular profiling data. For regulatory relationship …

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

L Higginbotham, L Ping, EB Dammer, DM Duong… - Science …, 2020 - science.org
… the AD brain network proteome into clinically useful systems-based biomarkers, we integrated
this brain-derived network with proteomic analysis of AD CSF. This integrative approach …

Metabolomics bridging proteomics along metabolites/oncometabolites and protein modifications: paving the way toward integrative multiomics

S Nalbantoglu, A Karadag - Journal of Pharmaceutical and Biomedical …, 2021 - Elsevier
… spectacular network of intertwined metabolic pathways makes integrated proteomics and
metabolomics an excellent opportunity, and the central component of integrative multiomics …

An Integrated Proteomic and Glycoproteomic Investigation Reveals Alterations in the N-Glycoproteomic Network Induced by 2-Deoxy-D-Glucose in Colorectal Cancer …

C Ma, HY Tsai, Q Zhang, L Senavirathna, L Li… - International Journal of …, 2022 - mdpi.com
integrated approach to glycoproteomics and proteomics, we characterized the 2DG-induced
alterations in N-glycosylation, as well as the cascading impacts on the whole proteome