The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
… -19 patients, indicating that the virus has evolved to escape the IFN-mediated antiviral immunity.
… Our understanding of the pathophysiology of SARS-CoV-2 infection and CSs has been …

A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
… This “Cytokine Storm,” has gained widespread attention as it is associated with severely
ill … of pro-inflammatory cytokines and chemokines produces the cytokine storm, resulting in …

Immune response resetting as a novel strategy to overcome SARS-CoV-2–induced Cytokine Storm

AE Nowill, PO de Campos-Lima - The Journal of Immunology, 2020 - journals.aai.org
… The virus-induced cytokine storm puts the immune system in … as well as the pathophysiological
changes found in the lungs. … -19), which rapidly evolved into one of the most aggressive …

The multifaceted immunology of cytokine storm syndrome

PY Lee, RQ Cron - The Journal of Immunology, 2023 - journals.aai.org
… of genes with defects associated with CSS is rapidly evolving (43). This includes genes
important … have been shown to contribute to CSS pathophysiology, likely via a threshold model of …

The looming storm: blood and cytokines in COVID-19

S Kaur, R Bansal, S Kollimuttathuillam, AM Gowda… - Blood reviews, 2021 - Elsevier
… of various hematological abnormalities including cytokine storm, … hematological presentations,
pathophysiology, and complications … There is evolving evidence that SARS-COV-2 causes …

Atherosclerosis as pathogenetic substrate for Sars-Cov2 cytokine storm

M Vinciguerra, S Romiti, K Fattouch, A De Bellis… - Journal of Clinical …, 2020 - mdpi.com
… atherosclerotic evolution due to excessive and aberrant plasmatic concentration of cytokines.
… The activation of complement system is found in the pathophysiology of ARDS, with …

COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics—a review

CTD Raj, DK Kandaswamy, RCSR Danduga… - Archives of …, 2021 - Springer
… In the cis signal transduction pathway, the IL-6 complex with a transmembrane form of IL-6R …
cells which contribute to cytokine storm. In trans signal pathway, IL-6 forms complex with …

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
… To the best of our knowledge, previous studies have reviewed the role of cytokine storm in
… and thorough review of cytokine storm pathophysiology mechanisms and discusses how it …

Pathophysiology and potential therapeutic candidates for COVID-19: a poorly understood arena

A Samaddar, M Grover, VL Nag - Frontiers in pharmacology, 2020 - frontiersin.org
… in the Wuhan City of China in December 2019 and evolved into a global pandemic. To date,
… release of pro-inflammatory cytokines, leading to a cytokine storm which is responsible for …

Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

A Shafqat, S Shafqat, SA Salameh, J Kashir… - Frontiers in …, 2022 - frontiersin.org
pathophysiological mechanisms causing COVID-19 respiratory and systemic disease. Spillover
of lung-derived cytokines causing a cytokine storm … extent of cytokine storm is insufficient …