… hepatic transporters in pharmacokinetics and drug-drug interactions (DDIs). Special emphasis
is placed on transporters … 1B3 emerged as important hepatic drug uptake pathways, sites …

… that the impact of hepatic BCRP on the overall pharmacokinetics of BCRP substrates cannot
… pharmacokinetics of drugs is probably much larger than at the canalicular side of liver cells. …

… Recent years have seen great advances in our ability to predict transporter-mediated
pharmacokinetics and drug interactions. Decision trees for determining when clinical …

… pharmacokinetics (PK) variability,[Citation6] transporter … Since hepatic drug transporters are
the focus of this review, … , it should be noted that these transporters play a critical role in the …

… Clinical DDIs of montelukast were evaluated using physiologically based pharmacokinetic
… pharmacokinetics. In conclusion, hepatic uptake plays a key role in the pharmacokinetics of …

… with hepatic impairment, there is potential for strong alterations of drug pharmacokinetics due
… reaction) have shown that many hepatic drug-metabolising enzymes and transporters are …

… Based on the recognition that hepatic transporters play a pivotal role in hepatic drug … action
of transporters into pharmacokinetic models describing the hepatic clearance of drugs, such …

… -19 drugs with tissue barrier membrane transporters 31 , while … the key hepatocellular
transporters involved in hepatic drug … of in vivo pharmacokinetic properties and potential drug-drug …

… evidence suggests hepatic uptake transporters, organic anion-transporting polypeptides (OATPs),
are of high clinical relevance in determining the pharmacokinetics of substrate drugs, …

… summary, hepatic OCT1 was recently demonstrated to be a key clearance mechanism for
several drugs, … These studies established hepatic OCT1 as a clinically important mechanism of …