… Fixed dosing of oral targeted therapies is inadequate in the era of precision medicine. …
studies are needed to confirm the clinical value of precision dosing in oncology. PK-based …

… of precision dosing in oncology. For alectinib, a randomized study on TDM-guided dosing
is … that pharmacokinetically guided dose optimization of oral targeted therapies is feasible in …

… of targeted therapies. Based on these examples and the associated principles for the
implementation of precision dosing, … , real-world approach to the best use of precision medicines. …

… multiple different precision dosing strategies … precision dosing of targeted cancer medicines
and is followed by a comprehensive comparison of the nuances between precision dosing …

… precision dosing targets correct and the best for all patients? In this review, the types of precision
dosing targets … with the translatability of these targets to individual patients are identified…

… cascade of target-based agents and the difficult challenge of bringing individualized precision
… (PD) factors, and drug selection and dosing should take this into consideration to optimize …

… drugs should be prioritized for precision dosing, nor which drug and disease criteria should
be considered. Therefore, we propose that the need for precision dosing can be informed by …

… The new challenges have led to a wide range of dose-limiting toxicities identified in phase
I trials of the targeted therapies, as they are based on the extrapolated safety profile of the …

… dosing for targeted therapies in oncology initiatives such as Project Optimus (from the Food
and Drug Administration) [6] aim to refine dose … Model-informed precision dosing combines …

… with targeted therapies developed to be specific to those genetic or genomic abnormalities.
The process of precision … based on a patient’s data and follow specific drug dosing regimens. …