Deformation characteristics and reactivation mechanism of an old landslide induced by combined action of excavation and heavy rainfall

Z Dai, L Yang, N Zhang, C Zhang, Z Zhang… - Frontiers in Earth …, 2023 - frontiersin.org
… The reactivation of an old landslide is usually the result of multiple factors, among which …
Many old landslides have reactivated under the combined action of human engineering …

Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1

J Finley - Medical hypotheses, 2016 - Elsevier
reactivating latent viral reservoirs do so via T cell activation-induced latent HIV-1 reactivation
) have each been shown alone or in combination to efficiently reactivate latent HIV-1 viral …

Highlights in resistance mechanism pathways for combination therapy

JMA Delou, ASO Souza, LCM Souza, HL Borges - Cells, 2019 - mdpi.com
… for ERK reactivation. As of May 2019, the FDA has approved a total of three BRAF/MEK
combination regimens, with the dabrafenib and trametinib combination being indicated for the …

Resurrection and reactivation of acetylcholinesterase and butyrylcholinesterase

AJ Franjesevic, SB Sillart, JM Beck… - … A European Journal, 2019 - Wiley Online Library
reactivate select OP-inhibited acetylcholinesterase (AChE). Yet, the fields of reactivation of
… encounter additional challenges as broad-spectrum reactivation of either enzyme is difficult. …

Facilitation of hippocampal long-term potentiation and reactivation of latent HIV-1 via AMPK activation: common mechanism of action linking learning, memory, and …

J Finley - Medical hypotheses, 2018 - Elsevier
… that AMPK links latent HIV-1 reactivation with hippocampal LTP, learning, and … reactivate
latent HIV-1 (eg PMA, ionomycin, resveratrol, metformin, etc.) either alone or in combination

A systematic analysis of signaling reactivation and drug resistance

BN Kholodenko, N Rauch, W Kolch, OS Rukhlenko - Cell reports, 2021 - cell.com
mechanisms that lead to complete pathway reactivation or overshoot, we identify network
topologies that can mediate full pathway reactivation … required for full reactivation or increase of …

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

L Gorecki, J Korabecny, K Musilek, D Malinak… - Archives of …, 2016 - Springer
… The mechanism of reactivation is believed to include nucleophilic attack of phosphorus
atom of inhibited AChE, resulting in removal of OP bond and recovery of enzyme’s catalytic …

Eye movement desensitization and reprocessing and slow wave sleep: a putative mechanism of action

M Pagani, BL Amann, R Landin-Romero… - Frontiers in …, 2017 - frontiersin.org
… The combined action of these two signals, as described above, potentiates … reactivated and
long-term potentiation is induced. During REM sleep, a further potentiation of the reactivated

Heterogeneous HIV-1 reactivation patterns of disulfiram and combined disulfiram+ romidepsin treatments

A Kula, N Delacourt, S Bouchat, G Darcis… - JAIDS Journal of …, 2019 - journals.lww.com
… In this report, we evaluated reactivation potential of DSF alone or combined with romidepsin
in vitro in various latency cell lines of myeloid and T-lymphocytic origins and ex vivo in CD8 …

PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in …

A Perdrix, A Najem, S Saussez, A Awada, F Journe… - Cancers, 2017 - mdpi.com
… Accordingly, reactivation of p53 appears as a quite … are PRIMA-1 (p53 reactivation and
induction of massive apoptosis … focus on their ability of p53 reactivation, an overview of their …