Quality by design approach for the preparation of fat-soluble vitamins lipid injectable emulsion

Y Deng, G Zhong, Y Wang, N Wang, Q Yu… - International Journal of …, 2019 - Elsevier
The fat-soluble vitamins lipid injectable emulsion, a parenteral supplement, commonly used
for hospitalized patients to meet daily requirements of fat-soluble vitamins. This study …

“Vitamin E” fortified parenteral lipid emulsions: Plackett–Burman screening of primary process and composition parameters

A Alayoubi, M Nazzal, PW Sylvester… - Drug Development and …, 2013 - Taylor & Francis
The objective of this study was to screen the effect of eight formulations and process
parameters on the physical attributes and stability of “Vitamin E”-rich parenteral lipid …

Droplet-size distribution and stability of commercial injectable lipid emulsions containing fish oil

C Gallegos, C Valencia, P Partal… - American Journal of …, 2012 - academic.oup.com
Purpose The droplet size of commercial fish oil-containing injectable lipid emulsions,
including conformance to United States Pharmacopeia (USP) standards on fat-globule size …

A New Control Strategy for High-Pressure Homogenization to Improve the Safety of Injectable Lipid Emulsions

C Grumbach, V Krüger, P Czermak - Pharmaceutics, 2022 - mdpi.com
Intravenous lipid emulsions are biocompatible formulations used as clinical nutrition
products and lipid-based delivery systems for sparingly soluble drugs. However, the particle …

[PDF][PDF] Lipid based self emulsifying formulations for poorly water soluble drugs-an excellent opportunity

K Mohsin, AA Shahba, FK Alanazi - Indian J. Pharm. Educ. Res, 2012 - ijper.org
Currently more than 50% of compounds identified are water insoluble and or poorly water
soluble. These molecules are difficult to formulate using conventional approaches (for their …

Quality by design case study 1: Design of 5-fluorouracil loaded lipid nanoparticles by the W/O/W double emulsion—Solvent evaporation method

G Amasya, U Badilli, B Aksu, N Tarimci - European Journal of …, 2016 - Elsevier
Abstract With Quality by Design (QbD), a systematic approach involving design and
development of all production processes to achieve the final product with a predetermined …

D-optimal Mixture Design for Optimized Microencapsulation of Vitamin A Palmitate and Its Characterizations

B De, TK Goswami - Journal of food engineering and technology, 2022 - xpublication.com
Food fortification is an effective intervention strategy for combating micronutrient
deficiencies. Vitamin A can be fortified in a wide range of food vehicles. In this research …

Approaches for the development of solid and semi-solid lipid-based formulations

V Jannin, J Musakhanian, D Marchaud - Advanced drug delivery reviews, 2008 - Elsevier
Interest in Lipid Based Drug Delivery (LBDD) has developed over the past decade fuelled by
a better understanding of the multiple roles lipids may play in enhancing oral bioavailability …

Development and characterization of stabilized omega-3 fatty acid and micronutrient emulsion formulation for food fortification

AA Jagtap, YS Badhe, MV Hegde… - Journal of Food Science …, 2021 - Springer
We report a novel stabilized emulsified formulation containing omega-3 fatty acid (ω-3 FA)
and micronutrient that can be readily used for food fortification. The emulsification …

Injectable lipid emulsions—advancements, opportunities and challenges

K Hippalgaonkar, S Majumdar, V Kansara - Aaps Pharmscitech, 2010 - Springer
Injectable lipid emulsions, for decades, have been clinically used as an energy source for
hospitalized patients by providing essential fatty acids and vitamins. Recent interest in …