Cytokine drizzle—the rationale for abandoning “cytokine storm”

AE Stolarski, J Kim, Q Zhang, DG Remick - Shock, 2021 - journals.lww.com
Background:“Cytokine storm” has been used to implicate increased cytokine levels in the
pathogenesis of serious clinical conditions. Similarities with Severe Acute Respiratory …

Cytokine and cytokine storm.

YL Wang, F Wang, J Geng - 2020 - cabidigitallibrary.org
Cytokines are a diverse group of small molecule proteins or peptides that are secreted by
cells for the purpose of intercellular delivery signaling and communication, which play an …

Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis

LK Weaver, EM Behrens - Current treatment options in rheumatology, 2017 - Springer
Opinion statement Cytokine storm syndromes require rapid diagnosis and treatment to limit
the morbidity and mortality caused by the hyperinflammatory state that characterizes these …

Constitutive inflammatory cytokine storm: a major threat to human health

KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
Immune cells secrete small protein molecules that aim for cell–cell communications. These
small molecules are called cytokines. Targeting cancer cells with administration of bispecific …

Comparison of the characteristics of cytokine storm and immune response induced by SARS-CoV, MERS-CoV, and SARS-CoV-2 infections

T Liu, M Feng, Z Wen, Y He, W Lin… - Journal of Inflammation …, 2021 - Taylor & Francis
Cytokine storm (CS) is a significant cause of death in patients with severe coronavirus
pneumonia. Excessive immune–inflammatory reaction, many inflammatory cell infiltration …

Cytokine storms in infectious diseases

JR Teijaro - Seminars in immunopathology, 2017 - Springer
The term Bcytokine storm^ has been adopted in the past several decades as a phrase to
describe the aberrant production of soluble mediators and the accompanying …

A cytokine circus with a viral ringleader: SARS-CoV-2-associated cytokine storm syndromes

SS Cabler, AR French, A Orvedahl - Trends in Molecular Medicine, 2020 - cell.com
An unbridled host immune response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been …

Safety and efficacy of tocilizumab in the treatment of severe acute respiratory syndrome coronavirus-2 pneumonia: a retrospective cohort study

A Patel, K Shah, M Dharsandiya, K Patel, T Patel… - Indian Journal of …, 2020 - Elsevier
Background: Cytokine release storm (CRS) in severe acute respiratory syndrome
coronavirus-2 (SARS CoV-2) is thought to be the cause for organ damage and death which …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?

MJ Ombrello, GS Schulert - Translational Research, 2021 - Elsevier
Although interest in “cytokine storms” has surged over the past decade, it was massively
amplified in 2020 when it was suggested that a subset of patients with COVID-19 developed …