The Optimization and Production of Ginkgolide B Lipid Microemulsion

X Wu, Z Wang, Z Zhao, L Chen, F Tao, Q Zhang… - Open …, 2019 - degruyter.com
In this study, we introduce a method to formulate Ginkgolide B lipid microemulsion (GB-LM).
We have assessed its general characteristics and pharmacokinetics in animals. Soybean oil …

A novel oil-body nanoemulsion formulation of ginkgolide B: pharmacokinetics study and in vivo pharmacodynamics evaluations

P Yang, X Cai, K Zhou, C Lu, W Chen - Journal of pharmaceutical sciences, 2014 - Elsevier
The goal of this study was to develop a novel oil-body nanoemulsion (ONE) for Ginkgolide B
(GB) and to conduct pharmacokinetics and pharmacodynamics evaluations. GB-ONE was …

Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method

M Liu, JH Chen, FR Dong, Y Liu - Nan Fang yi ke da xue xue bao …, 2008 - europepmc.org
Objective To optimize the formulation of long-circulating solid lipid nanoparticles (LSLN)
carrying ginkgolides A and B (GAB) extracted from traditional Chinese medicinal herbs …

Preparation and characterisation of ginkgolide nanoparticles via the emulsion solvent evaporation method

J Jiang, J Ao, C He, J Xiong, J Zhao, J Liu… - Micro & Nano …, 2018 - Wiley Online Library
Ginkgolide is the first choice for treatment of cardiovascular and cerebrovascular diseases.
However, its conventional dosage form (ginkgolide injection) can easily produce side effects …

Development of ligustrazine-loaded lipid emulsion: formulation optimization, characterization and biodistribution

L Wei, N Marasini, G Li, CS Yong, JO Kim… - International Journal of …, 2012 - Elsevier
Ligustrazine is a traditional Chinese medicine used to treat various cardiovascular and
neurovascular complications. However, this compound exhibits rapid first-pass metabolism …

Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique

H Li, T Pan, Y Cui, X Li, J Gao, W Yang… - International journal of …, 2016 - Taylor & Francis
The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME)
for oral administration to improve its solubility and enhance its bioavailability. Based on a …

Pharmacokinetics of ginkgolide B–lyophilized nanoparticles after intravenous injection in rats using liquid chromatography–tandem mass spectrometry

L Ma, L Zhu, J Peng, S Xu, Y Zhao, J Shi… - Rapid …, 2023 - Wiley Online Library
Rationale Ginkgolide B (GB) performs diverse pharmacological activities but has poor water
solubility. The currently available GB injections have a short half‐life and are lethal when …

[PDF][PDF] Development, characterization and cytotoxicity evaluation of Gingko biloba extract (EGB761) loaded microemulsion for intra-nasal application

M Singh, SP Singh, R Rachana - Journal of Applied Pharmaceutical …, 2017 - japsonline.com
Background: Ginkgo biloba is therapeutically important fossil species with extended benefits
against CNS disorders as; it contains various potential constituents which are known for their …

Preparation and in vitro release of ginkgolide B nanosuspension

J Wang, JJ Zhu, BD Shen, T Zhang… - Zhongguo Zhong yao …, 2020 - europepmc.org
To prepare ginkgolide B nanosuspension (GB-NS), and investigate its dissolution behaviors
in vitro. The miniaturized media milling method was used to prepare nanosuspensions, with …

Optimization of the preparation conditions of borneol-modified ginkgolide liposomes by response surface methodology and study of their blood brain barrier …

Z Lv, Y Yang, J Wang, J Chen, J Li, L Di - Molecules, 2018 - mdpi.com
Ginkgolides (GG), containing ginkgolide A (GA), ginkgolide B (GB) and ginkgolide C (GC),
are mainly prescribed for ischemic stroke and cerebral infarction. However, the ginkgolides …