The kidney is among the best characterized developing tissues, with the genes and
signaling pathways that regulate embryonic and adult kidney patterning and development …

Epigenetics is the study of heritable changes in DNA or its associated proteins except
mutations in gene sequence. Epigenetic regulation plays fundamental roles in the …

In the developing kidney, self-renewing progenitors respond to inductive signaling from the
adjacent branching ureteric bud by undergoing mesenchyme-to-epithelium transition …

Developmental changes in cell fate are tightly regulated by cell-type specific transcription
factors. Chromatin reorganization during organismal development ensures dynamic access …

The study of epigenetics is intimately linked and inseparable from developmental biology.
Many of the genes that imprint epigenetic information on chromatin function during the …

Chronic kidney disease (CKD) is a major public health concern and its prevalence and
incidence are rising quickly. It is a non-communicable disease primarily caused by diabetes …

Epigenetic mechanisms are fundamental key features of developing cells connecting
developmental regulatory factors to chromatin modification. Changes in the environment …

The mammalian kidney maintains fluid homeostasis through diverse epithelial cell types
generated from nephron and ureteric progenitor cells. To extend a developmental …

In mammals, formation of new nephrons ends perinatally due to consumption of
mesenchymal progenitor cells. Premature depletion of progenitors due to prematurity or …

DNA methylation and histone modifications determine renal programming and the
development and progression of renal disease. The identification of the way in which the …