PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …

PPARs and adipocyte function

C Christodoulides, A Vidal-Puig - Molecular and cellular endocrinology, 2010 - Elsevier
For long viewed as passive lipid storage depots, adipocytes are now recognised as key
players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last …

Pivotal roles of peroxisome proliferator-activated receptors (PPARs) and their signal cascade for cellular and whole-body energy homeostasis

S Lamichane, B Dahal Lamichane… - International journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor
superfamily, are important in whole-body energy metabolism. PPARs are classified into …

PPARs and metabolic disorders associated with challenged adipose tissue plasticity

P Corrales, A Vidal-Puig, G Medina-Gómez - International Journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are members of a family of nuclear
hormone receptors that exert their transcriptional control on genes harboring PPAR …

[HTML][HTML] An essential regulator of adipogenesis and modulator of fat cell function: PPARγ

BB Lowell - Cell, 1999 - cell.com
The most important function of adipose tissue is its ability to store and release fat during
periods of feeding and fasting. This allows food intake to be intermittent, freeing up time for …

Deciphering the roles of PPARγ in adipocytes via dynamic change of transcription complex

X Ma, D Wang, W Zhao, L Xu - Frontiers in endocrinology, 2018 - frontiersin.org
Peroxisome proliferator-activated receptor γ (PPARγ), a ligand-dependent transcription
factor highly expressed in adipocytes, is a master regulator of adipogenesis and lipid …

Peroxisome proliferator-activated receptor-γ: master regulator of adipogenesis and obesity

X Shao, M Wang, X Wei, S Deng, N Fu… - Current stem cell …, 2016 - ingentaconnect.com
Obesity, which is a key risk for the development of hyperglycemia, hypertension,
hyperlipidemia and insulin resistance and is totally referred to as the metabolic disorders …

PPARs as nuclear receptors for nutrient and energy metabolism

F Hong, S Pan, Y Guo, P Xu, Y Zhai - Molecules, 2019 - mdpi.com
It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Fat poetry: a kingdom for PPARγ

SI Anghel, W Wahli - Cell research, 2007 - nature.com
Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a
sophisticated ensemble of cellular components with highly specialized and complex …

Functional regulation of PPARs through post-translational modifications

R Brunmeir, F Xu - International journal of molecular sciences, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor
superfamily and they are essential regulators of cell differentiation, tissue development, and …