The age-associated decline of the neurological and cognitive functions becomes more and
more serious challenge for the developed countries with the increasing number of aged …

The current pathogenic scenarios of different types of dementia are based on a number of
common mechanisms of neurodegeneration, such as accumulation of abnormal proteins …

The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular
component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and …

The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

During the last decade, several articles have reported a relationship between advanced age
and changes in the integrity of the blood-brain barrier (BBB). These changes were …

Aims While vascular pathology is a common feature of a range of neurodegenerative
diseases, we hypothesized that vascular changes occur in association with normal ageing …

The blood-brain barrier (BBB) is a complex and dynamic physiological interface between
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …