Background Schizophrenia is caused by a combination of genetic and environmental
factors, as first evidenced by twin studies. Extensive efforts have been made to identify the …

Background Therapeutic treatments for schizophrenia do not alleviate symptoms for all
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …

Background Schizophrenia is the collective term for an exclusively clinically diagnosed,
heterogeneous group of mental disorders with still obscure biological roots. Based on the …

This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …

Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …

Epidemiologists and geneticists have tended to explore their respective domains
independently, and as a consequence, these fields have drifted apart. The aim of this article …

The influence of genetic factors in the development of schizophrenia has been convincingly
demonstrated by family, twin, and adoption studies. The statistical construct of heritability is …

Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for
the disorder may differ between the sexes or between multiply affected families compared to …

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …