Strategies to enhance the solubility and bioavailability of tocotrienols using self-emulsifying drug delivery system

NV Mohamad - Pharmaceuticals, 2023 - mdpi.com
Tocotrienols have higher medicinal value, with multiple sources of evidence showing their
biological properties as antioxidant, anti-inflammatory, and osteoprotective compounds …

Enhanced solubility and oral bioavailability of γ-Tocotrienol using a self-emulsifying drug delivery system (SEDDS)

S Alqahtani, A Alayoubi, S Nazzal, PW Sylvester… - Lipids, 2014 - Springer
The aim of this study was to evaluate the in vitro and in vivo performance of γ-tocotrienol (γ-
T3) incorporated in a self-emulsifying drug delivery system (SEDDS) and to compare its …

Formulation and in vivo evaluation of a solid self-emulsifying drug delivery system using oily liquid tocotrienols as model active substance

YZ Lee, EK Seow, SC Lim, KH Yuen… - Pharmaceutics, 2021 - mdpi.com
Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of
poorly water-soluble drugs. Solid self-emulsifying drug delivery systems (s-SEDDS) offer …

Nonlinear Absorption Kinetics of Self-Emulsifying Drug Delivery Systems (SEDDS) Containing Tocotrienols as Lipophilic Molecules: In Vivo and In Vitro Studies

S Alqahtani, A Alayoubi, S Nazzal, PW Sylvester… - The AAPS journal, 2013 - Springer
Self-emulsifying drug delivery systems (SEDDS) have been broadly used to promote the
oral absorption of poorly water-soluble drugs. The purpose of the current study was to …

Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations

SP Yap, KH Yuen - International journal of pharmaceutics, 2004 - Elsevier
A single dose comparative bioavailability study was conducted to evaluate the bioavailability
of tocotrienols from two self-emulsifying formulations, one of which produced an emulsion …

Pharmacokinetics and bioavailability of α-, γ-and δ-tocotrienols under different food status

SP Yap, KH Yuen, JW Wong - Journal of Pharmacy and …, 2001 - academic.oup.com
We have investigated the pharmacokinetics and bioavailability of α-, γ-and δ-tocotrienols
under fed and fasted conditions in eight healthy volunteers. The volunteers were …

β-Sitosterol loaded nanostructured lipid carrier: Physical and oxidative stability, in vitro simulated digestion and hypocholesterolemic activity

Y Soleimanian, SAH Goli, J Varshosaz… - Pharmaceutics, 2020 - mdpi.com
The objective of the present study was to explore the potential of nanostructured lipid
carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble …

Effect of nano-delivery systems on the bioavailability and tissue biodistribution of vitamin E tocotrienols

JY Fu, P Meganathan, N Gunasegaran… - Food Research …, 2023 - Elsevier
Vitamin E is one of the most important essential vitamins to support the regulation of
oxidative stress in human body. Tocotrienols are part of the vitamin E family. The potentials …

Effects of environmental stresses and in vitro digestion on the release of tocotrienols encapsulated within chitosan-alginate microcapsules

PY Tan, TB Tan, HW Chang, BT Tey… - Journal of agricultural …, 2017 - ACS Publications
Considering the health benefits of tocotrienols, continuous works have been done on the
encapsulation and delivery of these compounds. In this study, we encapsulated tocotrienols …

Emulsions as delivery systems for gamma and delta tocotrienols: formation, properties and simulated gastrointestinal fate

F Xu, JK Pandya, C Chung, DJ McClements… - Food Research …, 2018 - Elsevier
Tocotrienols have been reported to have stronger bioactivities than tocopherols, and may
therefore be suitable as a potent source of vitamin E in functional foods, supplements, and …