Enzymatic Processes of the Preparation of Esters of Poorly Water-Soluble Carboxylic Acids
F Zappaterra - 2021 - sfera.unife.it
The bioavailability of an active ingredient of industrial interest is the parameter that most
influences its translation to a marketable bioactive molecule. Bioavailability is largely …
influences its translation to a marketable bioactive molecule. Bioavailability is largely …
Enzymatic synthesis of ibuprofen monoglycerides catalyzed by free Candida antarctica lipase B in a toluene–glycerol biphasic medium
The enzymatic esterification of glycerol and ibuprofen in different organic media to obtain a
monoester of ibuprofen was studied in an open and close system, selecting an adequate …
monoester of ibuprofen was studied in an open and close system, selecting an adequate …
Synthesis of Ibuprofen Monoglyceride Using Novozym® 435: Biocatalyst Activation and Stabilization in Multiphasic Systems
M Ravelo Velasquez, ME Gallardo, M Ladero Galán… - 2022 - docta.ucm.es
This work was focused on the enzymatic esterification of glycerol and ibuprofen at high
concentrations in two triphasic systems composed of toluene+ ibuprofene (apolar) and …
concentrations in two triphasic systems composed of toluene+ ibuprofene (apolar) and …
Synthesis of Ibuprofen Monoglyceride Using Novozym®435: Biocatalyst Activation and Stabilization in Multiphasic Systems
This work was focused on the enzymatic esterification of glycerol and ibuprofen at high
concentrations in two triphasic systems composed of toluene+ ibuprofene (apolar) and …
concentrations in two triphasic systems composed of toluene+ ibuprofene (apolar) and …
Synthesis of Ibuprofen Monoglyceride in Solventless Medium with Novozym®435: Kinetic Analysis
This study investigates the enzymatic esterification of glycerol and ibuprofen in a solventless
medium catalyzed by immobilized lipase B from Candida antarctica (Novozym® 435). Fixing …
medium catalyzed by immobilized lipase B from Candida antarctica (Novozym® 435). Fixing …
Biocatalytic approach for direct esterification of ibuprofen with sorbitol in biphasic media
F Zappaterra, MEM Rodriguez, D Summa… - International Journal of …, 2021 - mdpi.com
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) introduced in the 1960s and
widely used as an analgesic, anti-inflammatory, and antipyretic. In its acid form, the solubility …
widely used as an analgesic, anti-inflammatory, and antipyretic. In its acid form, the solubility …
On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen
O Khiari, N Bouzemi, JM Sánchez-Montero… - Catalysts, 2023 - mdpi.com
In this paper, we describe the effectiveness of the combination between an organic solvent
system mixture with orthoformates with different chain sizes from one to four carbon atoms …
system mixture with orthoformates with different chain sizes from one to four carbon atoms …
A facile enzymatic process for the preparation of ibuprofen ester prodrug in organic media
XG Zhao, DZ Wei, QX Song - Journal of Molecular Catalysis B: Enzymatic, 2005 - Elsevier
A novel glucopyranoside derivative of ibuprofen, ibuprofen methyl α-d-glucopyranoside
ester was synthesized via immobilized lipase-catalyzed esterification between racemic …
ester was synthesized via immobilized lipase-catalyzed esterification between racemic …
Lipase-catalyzed enantioselective esterification of ibuprofen in organic solvents under controlled water activity
A Ducret, M Trani, R Lortie - Enzyme and Microbial Technology, 1998 - Elsevier
The enantioselective esterification of ibuprofen (2-(4-iso-butylphenyl) propionic acid),
catalyzed by Candida antarctica lipase (type B), was performed in various organic solvents …
catalyzed by Candida antarctica lipase (type B), was performed in various organic solvents …
Esterification of glycerol and ibuprofen in solventless media catalyzed by free CALB: Kinetic modelling
The enzymatic reaction of ibuprofen and glycerol in solventless media without and with the
optimum content in water to obtain ibuprofen monoester is studied, selecting an adequate …
optimum content in water to obtain ibuprofen monoester is studied, selecting an adequate …