Stroke proteomics: from discovery to diagnostic and therapeutic applications

K Hochrainer, W Yang - Circulation research, 2022 - Am Heart Assoc
Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Application of proteomics to cerebrovascular disease

MM Ning, M Lopez, J Cao, FS Buonanno… - Electrophoresis, 2012 - Wiley Online Library
While neurovascular diseases such as ischemic and hemorrhagic stroke are the leading
causes of disability in the world, the repertoire of therapeutic interventions has remained …

Protein biomarkers for traumatic and ischemic brain injury: from bench to bedside

Z Zhang, S Mondello, F Kobeissy, R Rubenstein… - Translational Stroke …, 2011 - Springer
Stroke is the second leading cause of death worldwide and the third leading cause of death
in the USA. A clinically useful biomarker for the diagnosis of stroke does not currently exist …

Potential blood biomarkers for stroke

CM Laborde, L Mourino–Alvarez… - Expert review of …, 2012 - Taylor & Francis
Stroke is one of the most common causes of death worldwide and a major cause of acquired
disability in adults. Despite advances in research during the last decade, prevention and …

Proteomics reveals plasma biomarkers for ischemic stroke related to the coagulation cascade

J Lee, S Mun, A Park, D Kim, YJ Lee, HJ Kim… - Journal of Molecular …, 2020 - Springer
Stroke has a high incidence rate and often leads to permanent disability, particularly if it is
not treated promptly. However, no blood biomarkers for early diagnosis are available to …

Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects

F Kobeissy, M Goli, H Yadikar, Z Shakkour… - Frontiers in …, 2023 - frontiersin.org
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …

Identification of novel biomarkers of brain damage in patients with hemorrhagic stroke by integrating bioinformatics and mass spectrometry-based proteomics

E Martínez-Morillo, P García Hernández… - Journal of Proteome …, 2014 - ACS Publications
Hemorrhagic stroke (HS) is a significant cause of mortality that requires rapid diagnosis and
prompt medical attention. A time-efficient diagnostic test to assist in the early classification of …

The proteome of human brain after ischemic stroke

E Cuadrado, A Rosell, N Colomé… - … of Neuropathology & …, 2010 - academic.oup.com
Although stroke is among the most common causes of death and chronic disability
worldwide, the proteome of the ischemic human brain remains unknown. Only a few studies …

Machine learning analysis of the cerebrovascular thrombi proteome in human ischemic stroke: an exploratory study

C Dargazanli, E Zub, J Deverdun… - Frontiers in …, 2020 - frontiersin.org
Objective: Mechanical retrieval of thrombotic material from acute ischemic stroke patients
provides a unique entry point for translational research investigations. Here, we resolved the …