Despite the high incidence and burden of stroke, biological biomarkers are not used
routinely in clinical practice to diagnose, determine progression, or prognosticate outcomes …

Background Proteomic analysis of cerebrospinal fluid (CSF) has shown great promise in
identifying potential markers of injury in neurodegenerative diseases 1, 2, 3, 4, 5, 6, 7, 8, 9 …

Ubiquitin modifications alter protein function and stability, thereby regulating cell
homeostasis and viability, particularly under stress. Ischemic stroke induces protein …

Platelets play a crucial role in the pathogenesis of stroke and antiplatelet agents exist for its
treatment and prevention. Through the use of LC-MS based protein expression profiling …

Neuroprotection strategies to improve stroke outcome have been successful in the
laboratory but not in clinical stroke trials, and thus have come under scrutiny by the medical …

The immense intercellular and intracellular heterogeneity of the CNS presents major
challenges for high-throughput omic analyses. Transcriptional, translational and post …

Biomarkers are objective indicators used to assess normal or pathological processes,
evaluate responses to treatment and predict outcomes. Many blood biomarkers already …

Proteomics is a field of study directed toward providing a comprehensive view of the
characteristics and activity of every cellular protein. Rapid innovations in the core …

Background The inflammatory response to cerebral ischemia is complex; however, most
clinical studies of stroke outcome focus on a few selected proteins. We, therefore, aimed to …

Abstract HUIBREGTSE, ME, Bazarian, JJ, Shultz, SR, and Kawata K. The biological
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …