Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of
overactive bladder and incontinence, provokes massive protein accumulation in the cytosol …

Male and female F344 rats but not B6C3F1 mice exposed for 104 weeks to propiverine
hydrochloride (1-methylpiperid-4-yl 2, 2-diphenyl-2-(1-propoxy) acetate hydrochloride) …

Proper subcellular trafficking is essential to prevent protein mislocalization and aggregation.
Transport of the peroxisomal enzyme d-amino acid oxidase (DAAO) appears dysregulated …

d-Serine selectively causes necrosis of S3 segments of proximal tubules in rats. This leads
to aminoaciduria and glucosuria. Coinjection of the nonmetabolizable amino acid α …

D-amino acid oxidase (DAO) is a flavoenzyme catalyzing the oxidation of D-amino acid (AA)
s. In the kidney, its expression is detected in proximal tubules, and DAO is considered to …

Reactive oxygen species (ROS) have been associated with many human diseases, and
glutathione (GSH)-dependent processes are pivotal in limiting tissue damage. To test the …

D-Aspartate oxidase (EC 1.4. 3.1) was assayed in subcellular fractions and in highly purified
peroxisomes from rat, bovine and sheep kidney cortex as well as from rat liver. During all …

d-Serine selectively damages renal proximal tubule cells in rats by a mechanism that is not
fully understood. Recent proteomic analysis identified that d-serine elevated plasma …

Background: Peroxisomes play important roles in metabolism, including in fatty acid
oxidation (FAO). Interestingly, post-translational modification of lysine residues by …

d‐amino acid oxidase (DAO) is a peroxisomal enzyme that catalyzes the oxidative
deamination of several neutral and basic d‐amino acids to their corresponding α‐keto acids …