Aim of the study The induced expression of the transcription factors neurogenin1 (Neurog1)
or neuronal differentiation 1 (NeuroD1) has previously been shown to initiate neuronal …

Differentiation of the pluripotent neuroepithelium into neurons and glia is accomplished by
the interaction of growth factors and cell-type restricted transcription factors. One approach …

Background: Delineating the cascades of growth and transcription factor expression that
shape the developing nervous system will improve our understanding of its molecular …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Embryonic stem (ES) cells and their derivatives are an important resource for developing
novel cellular therapies for disease. Controlling proliferation and lineage selection, however …

Recent studies show that combinations of defined key developmental transcription factors
(TFs) can reprogram somatic cells to pluripotency or induce cell conversion of one somatic …

Sensory perception is fundamental to everyday life, yet understanding of human sensory
physiology at the molecular level is hindered due to constraints on tissue availability …

Neural stem cells (NSCs) are important pluripotent stem cells, which have potential
applications in cell replacement therapy. Brain-derived neurotrophic factor (BDNF) and …

Direct lineage reprogramming of human fibroblasts into functional neurons holds great
promise for biomedical applications such as regenerative medicine and cellbased disease …

Wnts were previously shown to regulate the neurogenesis of neural stem or progenitor cells.
Here, we explored the underlying molecular mechanisms through which Wnt signaling …