The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

The formation and accumulation of advanced glycation endproducts (AGEs) are related to
diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl …

The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of
glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation …

Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …

SUMMARY A large literature has developed around methylglyoxal (MG) concerning its role
in diabetes mellitus (DM) and in the development of diabetic complications. This is related to …

Over the years, new research has elucidated the importance of the very fast formation of
AGEs by the highly reactive methylglyoxal (MGO). It has become clear that MGO triggers …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Methylglyoxal (MG) is a reactive dicarbonyl intermediate of the glycolytic pathway. Increased
oxidative stress is associated with conditions of increased MG, such as diabetes mellitus …

Methylglyoxal (MGO), a major precursor for advanced glycation end products, is increased
in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD) …