Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating
transport of most molecules to protect the brain microenvironment. Multiple structural and …

Recent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood–brain …

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to
Alzheimer-type pathology remains poorly defined. We have investigated the BBB in …

Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …

There is increasing recognition of the importance of blood–brain barrier (BBB) disruption in
aging, dementia, stroke and multiple sclerosis in addition to more commonly-studied …

Cerebral “microvascular” disease occurs in lacunar stroke, leukoaraiosis, vascular dementia
and Alzheimer's disease. It may arise from or contribute to insidious damage to the blood …

Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating
substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the …