Septic shock is mediated by complex interactions of cells, cytokines, and humoral pathways.
Clinical therapeutic strategies aimed at inhibiting selected pathways have been efficacious …

Severe sepsis leading to shock is the principal cause of death in non-cardiac intensive care
units. This condition develops because of a dysregulation in host responses, such that the …

Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality …

Septic shock is initiated by a systemic inflammatory response to microbial infection that
frequently leads to impaired perfusion and multiple organ failure. Because of its high risk of …

Consecutive exposures to different pathogens are highly prevalent and often alter the host
immune response. However, it remains unknown how a secondary bacterial infection affects …

Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …

The COVID-19 outbreak is emerging as a significant public health challenge. Excessive
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …

In sepsis and trauma, pathogens and injured tissue provoke a systemic inflammatory
reaction which can lead to overwhelming inflammation. Concurrent with the innate …