The blood-brain barrier in aging and neurodegeneration

EG Knox, MR Aburto, G Clarke, JF Cryan… - Molecular …, 2022 - nature.com
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging

Y Mou, Y Du, L Zhou, J Yue, X Hu, Y Liu… - Frontiers in …, 2022 - frontiersin.org
It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

The role of the blood–brain barrier during neurological disease and infection

A Patabendige, D Janigro - Biochemical Society Transactions, 2023 - portlandpress.com
A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the
endothelial cells that line brain capillaries. The BBB plays an extremely important role in …

The impact of gut microbiota disorders on the blood–brain barrier

W Tang, H Zhu, Y Feng, R Guo… - Infection and Drug …, 2020 - Taylor & Francis
The gut microbiota is symbiotic with the human host and has been extensively studied in
recent years resulting in increasing awareness of the effects of the gut microbiota on human …

Expert insights: the potential role of the gut microbiome‐bile acid‐brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy

W Jia, C Rajani, R Kaddurah‐Daouk… - Medicinal research …, 2020 - Wiley Online Library
Recent epidemiological and molecular studies have linked the disruption of cholesterol
homeostasis to increased risk for developing Alzheimer's disease (AD). Emerging evidence …

Gut reactions: How the blood–brain barrier connects the microbiome and the brain

AF Logsdon, MA Erickson, EM Rhea… - Experimental …, 2018 - journals.sagepub.com
A growing body of evidence indicates that the microbiome interacts with the central nervous
system (CNS) and can regulate many of its functions. One mechanism for this interaction is …

Blood–brain barrier disruption and its involvement in neurodevelopmental and neurodegenerative disorders

A Aragón-González, PJ Shaw, L Ferraiuolo - International journal of …, 2022 - mdpi.com
The blood–brain barrier (BBB) is a highly specialized and dynamic compartment which
regulates the uptake of molecules and solutes from the blood. The relevance of the …

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Of microbes and minds: a narrative review on the second brain aging

R Calvani, A Picca, MR Lo Monaco, F Landi… - Frontiers in …, 2018 - frontiersin.org
In recent years, an extensive body of literature focused on the gut–brain axis and the
possible role played by the gut microbiota in modulating brain morphology and function from …