Life expectancy has increased in most developed countries, which has led to an increase in
the proportion of elderly people in the world's population. However, this increase in life …

The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

The current pathogenic scenarios of different types of dementia are based on a number of
common mechanisms of neurodegeneration, such as accumulation of abnormal proteins …

The age-associated decline of the neurological and cognitive functions becomes more and
more serious challenge for the developed countries with the increasing number of aged …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Aging is a major risk factor for many human diseases, including cognitive impairment, which
affects a large population of the elderly. In the past few decades, our understanding of the …

The blood brain barrier is a necessity for cerebral homeostasis and response to
environmental insult, thus loss in functionality with age creates opportunities for disease to …

Since the development of antibiotics and vaccination, as well as major improvements in
public hygiene, the main risk factors for morbidity and mortality are age and chronic …

Aging of the human brain is associated with “normal” functional, structural, and molecular
changes that underlie alterations in cognition, memory, mood and motor function, amongst …

Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …