Aging as a research pursuit is fairly new compared with traditional lines of medical research.
A growing field of investigators is focused on understanding how changes in tissue biology …

Underlying the importance of research on the biology of aging is the fact that many nations
face the demographic reality of a rapidly aging populace and the looming healthcare …

For many years, it has been known that when rats and mice are given a reduced amount of
food, their life span is increased and they remain healthy and vigorous at advanced ages …

In regard to identifying interventions with potential human application, Panels 2 and 3
focused on an approach that complements the increasing interest in learning the …

Caloric restriction (CR) causes a reduction in body temperature (Tb) which is suggested to
contribute to changes that increase lifespan. Moreover, low Tb has been shown to improve …

The aging process results in a gradual and progressive structural deterioration of
biomolecular and cellular compartments and is associated with many pathological …

To examine molecular events associated with aging and its retardation by caloric restriction
(CR), we have employed high-density oligonucleotide microarrays to define transcriptional …

The complexity of aging is hard to be captured. However, apart from its tissue-specific
features, a structural and functional progressive decline of the whole organism that leads to …

Caloric restriction has been extensively investigated as an intervention that both extends
lifespan and delays age-related disease in mammals. In mice, much interest has centered …

The aging process is evolutionarily conserved and subject to quantitative modification by
both genetic and environmental factors. Fundamental mechanisms of aging result in …