Background Large numbers of autosomal sites are found differentially methylated in the
aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome …

The Y chromosome, a sex chromosome that only exists in males, has been ignored in
traditional epigenetic association studies for multiple reasons. However, sex differences in …

Background Ageing displays clear sexual dimorphism, evident in both morbidity and
mortality. Ageing is also associated with changes in DNA methylation, but very little focus …

Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …

Background It is well-known that methylation changes occur as humans age, however,
understanding how age-related changes in DNA methylation vary by sex is lacking. In this …

Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …

Background Epigenetics is one of the factors shaping natural variability observed among
human populations. A small proportion of heritable inter-population differences are …

Background There is increasing evidence for inter-individual methylation differences at CpG
dinucleotides in the human genome, but the regional extent and function of these …

Background: Between-and within-person variation in DNA methylation levels are important
parameters to be considered in epigenome-wide association studies. Temporal change is …

Background/Aim: This study aimed to measure the DNA methylation state of thousands of
CpG islands in the blood of two monozygotic twins that were discordant for cardiovascular …