Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

J Montaner, L Ramiro, A Simats, S Tiedt… - Nature Reviews …, 2020 - nature.com
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …

Multi-omics research strategies in ischemic stroke: A multidimensional perspective

W Li, C Shao, H Zhou, H Du, H Chen, H Wan… - Ageing Research …, 2022 - Elsevier
Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Biomarker application for precision medicine in stroke

AN Simpkins, M Janowski, HS Oz, J Roberts… - Translational stroke …, 2020 - Springer
Stroke remains one of the leading causes of long-term disability and mortality despite recent
advances in acute thrombolytic therapies. In fact, the global lifetime risk of stroke in adults …

Stroke proteomics: from discovery to diagnostic and therapeutic applications

K Hochrainer, W Yang - Circulation research, 2022 - Am Heart Assoc
Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Towards the identification of blood biomarkers for acute stroke in humans: a comprehensive systematic review

N Hasan, P McColgan, P Bentley… - British journal of …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Stroke is the largest single cause of
disability in the UK. While tests based upon biomarkers have been around for decades …

Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review

C Ke, CW Pan, Y Zhang, X Zhu, Y Zhang - Metabolomics, 2019 - Springer
Introduction Ischemic stroke (IS) is a major contributor to the global disease burden, and
effective biomarkers for IS management in clinical practice are urgently needed …

Stroke biomarkers in clinical practice: a critical appraisal

GJL Ng, AML Quek, C Cheung, TV Arumugam… - Neurochemistry …, 2017 - Elsevier
Biomarkers provide critical mechanistic insights to key biologic processes that occur during
cerebral ischemia which, when carefully applied, can improve clinical decision-making in …

[HTML][HTML] Biomarker for ischemic stroke using metabolome: a clinician perspective

E Sidorov, DK Sanghera, JKP Vanamala - Journal of stroke, 2019 - ncbi.nlm.nih.gov
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis
even before a patient arrives to the hospital. Metabolome is one of new technologies that …

Metabolomics and lipidomics of ischemic stroke

A Au - Advances in clinical chemistry, 2018 - Elsevier
Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain
tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics …

Acute stroke biomarkers: are we there yet?

M Dagonnier, GA Donnan, SM Davis… - Frontiers in …, 2021 - frontiersin.org
Background: Distinguishing between stroke subtypes and knowing the time of stroke onset
are critical in clinical practice. Thrombolysis and thrombectomy are very effective treatments …