Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
AF Pardiñas, P Holmans, AJ Pocklington… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …
Genetics of schizophrenia: ready to translate?
Abstract Purpose of Review This is an era where we have significantly advanced the
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
understanding of the genetic architecture of schizophrenia. In this review, we consider how …
[PDF][PDF] Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia
Schizophrenia is a severe psychiatric disorder with strong heritability and marked
heterogeneity in symptoms, course, and treatment response. There is strong interest in …
heterogeneity in symptoms, course, and treatment response. There is strong interest in …
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
individuals and performed further transancestry meta-analyses with data from the Psychiatry …
Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
globally. Large-scale schizophrenia genetic studies have reported primarily on European …
High-impact rare genetic variants in severe schizophrenia
Extreme phenotype sequencing has led to the identification of high-impact rare genetic
variants for many complex disorders but has not been applied to studies of severe …
variants for many complex disorders but has not been applied to studies of severe …
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach
DM Ruderfer, AW Charney, B Readhead… - The Lancet …, 2016 - thelancet.com
Background Therapeutic treatments for schizophrenia do not alleviate symptoms for all
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …
patients and efficacy is limited by common, often severe, side-effects. Genetic studies of …
Boosting the power of schizophrenia genetics by leveraging new statistical tools
OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …
associated with schizophrenia, but these variants explain only a small portion of the …
The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare …
BJ Mowry, J Gratten - Molecular psychiatry, 2013 - nature.com
After decades of halting progress, recent large genome-wide association studies (GWAS)
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …
are finally shining light on the genetic architecture of schizophrenia. The picture emerging is …