Expert insights: the potential role of the gut microbiome‐bile acid‐brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy

W Jia, C Rajani, R Kaddurah‐Daouk… - Medicinal research …, 2020 - Wiley Online Library
Recent epidemiological and molecular studies have linked the disruption of cholesterol
homeostasis to increased risk for developing Alzheimer's disease (AD). Emerging evidence …

Bile acids as key modulators of the brain-gut-microbiota axis in Alzheimer's disease

A Mulak - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Recently, the concept of the brain-gut-microbiota (BGM) axis disturbances in the
pathogenesis of Alzheimer's disease (AD) has been receiving growing attention. At the …

Microbiota-gut-brain axis in the Alzheimer's disease pathology-an overview

VV Giridharan, CEB De Quevedo, F Petronilho - Neuroscience Research, 2022 - Elsevier
Alzheimer's disease (AD) and related dementias (ADRD) are still a serious global public
health concern more than a century after the German neuropathologist and psychiatrist Dr …

A review of the brain-gut-microbiome axis and the potential role of microbiota in Alzheimer's disease

M Sun, K Ma, J Wen, G Wang, C Zhang… - Journal of …, 2020 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative process characterized by loss of neurons
in the hippocampus and cerebral cortex, leading to progressive cognitive decline …

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Gut microbiota and dysbiosis in Alzheimer's disease: implications for pathogenesis and treatment

S Liu, J Gao, M Zhu, K Liu, HL Zhang - Molecular neurobiology, 2020 - Springer
Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …

Manipulation of the diet–microbiota–brain axis in Alzheimer's disease

D Lee, VMY Lee, SK Hur - Frontiers in Neuroscience, 2022 - frontiersin.org
Several studies investigating the pathogenesis of Alzheimer's disease have identified
various interdependent constituents contributing to the exacerbation of the disease …

The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology

T Doifode, VV Giridharan, JS Generoso, G Bhatti… - Pharmacological …, 2021 - Elsevier
The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic
microbial cells. The microbiota, the gut, and the brain form an association,'the microbiota-gut …

The gut microbiome and Alzheimer's disease: Complex and bidirectional interactions

R Tarawneh, E Penhos - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have
emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) …

Dysbiosis and alzheimer's disease: cause or treatment opportunity?

MH Janeiro, MJ Ramírez, M Solas - Cellular and molecular neurobiology, 2022 - Springer
Recent investigations have increased the interest on the connection between the
microorganisms inhabiting the gut (gut microbiota) and human health. An imbalance of the …