Immune determinants of COVID-19 disease presentation and severity

P Brodin - Nature medicine, 2021 - nature.com
Abstract COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of
previously healthy individuals, but can cause life-threatening disease or persistent …

Sex differences in immune responses that underlie COVID-19 disease outcomes

T Takahashi, MK Ellingson, P Wong, B Israelow… - Nature, 2020 - nature.com
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more
severe symptoms and higher mortality among men than among women,,,–. However …

[HTML][HTML] COVID-19 infection: the perspectives on immune responses

Y Shi, Y Wang, C Shao, J Huang, J Gan… - Cell Death & …, 2020 - nature.com
More than 100 years since the outbreak of the 1918 influenza pandemic, we now seem to
face another pandemic. The outbreak of the new coronavirus (SARS-CoV-2) infection is …

A dynamic COVID-19 immune signature includes associations with poor prognosis

AG Laing, A Lorenc, I Del Molino Del Barrio, A Das… - Nature medicine, 2020 - nature.com
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …

The immunology and immunopathology of COVID-19

M Merad, CA Blish, F Sallusto, A Iwasaki - Science, 2022 - science.org
Considerable research effort has been made worldwide to decipher the immune response
triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …

[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19

C Lucas, P Wong, J Klein, TBR Castro, J Silva… - Nature, 2020 - nature.com
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …

Silent battles: immune responses in asymptomatic SARS-CoV-2 infection

N Le Bert, T Samandari - Cellular & Molecular Immunology, 2024 - nature.com
SARS-CoV-2 infections manifest with a broad spectrum of presentations, ranging from
asymptomatic infections to severe pneumonia and fatal outcomes. This review centers on …

Distinguishing features of Long COVID identified through immune profiling

J Klein, J Wood, JR Jaycox, RM Dhodapkar, P Lu… - Nature, 2023 - nature.com
Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …

Why do some people develop serious COVID-19 disease after infection, while others only exhibit mild symptoms?

M Ballow, CL Haga - The Journal of Allergy and Clinical Immunology: In …, 2021 - Elsevier
The year 2020 was a landmark year of a once-in-a-century pandemic of a novel coronavirus,
SARS-CoV-2 virus, that led to a rapidly spreading coronavirus disease (COVID-19). The …

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …