Glycolaldehyde, an advanced glycation end products precursor, induces apoptosis via ROS-mediated mitochondrial dysfunction in renal mesangial cells
MJ Gu, JY Hyon, HW Lee, EH Han, Y Kim, YS Cha… - Antioxidants, 2022 - mdpi.com
Glycolaldehyde (GA) is a reducing sugar and a precursor of advanced glycation end
products (AGEs). The role of precursor and precursor-derived AGEs in diabetes and its …
products (AGEs). The role of precursor and precursor-derived AGEs in diabetes and its …
Methylglyoxal-derived advanced glycation end product (AGE4)-induced apoptosis leads to mitochondrial dysfunction and endoplasmic reticulum stress through the …
SR Jeong, KW Lee - International journal of molecular sciences, 2021 - mdpi.com
Advanced glycation end products (AGEs) are formed via nonenzymatic reactions between
reducing sugars and proteins. Recent studies have shown that methylglyoxal, a potent …
reducing sugars and proteins. Recent studies have shown that methylglyoxal, a potent …
Glyoxal-derived advanced glycation end-products, Nε-carboxymethyl-lysine, and glyoxal-derived lysine dimer induce apoptosis-related gene expression in …
Background Advanced glycation end-products (AGEs) are proteins or lipids that have been
glycated nonenzymatically by reducing sugars and their derivatives such as methylglyoxal …
glycated nonenzymatically by reducing sugars and their derivatives such as methylglyoxal …
Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation
L Rodrigues, P Matafome, J Crisóstomo… - Journal of physiology …, 2014 - Springer
Hyperglycemia-related advanced glycation end product (AGE) formation is a key
mechanism in diabetic nephropathy. Since methylglyoxal (MG) is a potent AGE precursor …
mechanism in diabetic nephropathy. Since methylglyoxal (MG) is a potent AGE precursor …
Advanced glycation end products (AGEs) induce apoptosis via a novel pathway: involvement of Ca2+ mediated by interleukin-8 protein
S Mahali, N Raviprakash, PB Raghavendra… - Journal of Biological …, 2011 - ASBMB
Advanced glycation end products (AGEs) accumulate in diabetic patients due to high blood
glucose levels and cause multiple deleterious effects. In this study, we provide evidence that …
glucose levels and cause multiple deleterious effects. In this study, we provide evidence that …
[HTML][HTML] Toxic advanced glycation end-products (TAGE) are major structures of cytotoxic AGEs derived from glyceraldehyde
M Takeuchi, H Suzuki, K Takeda, A Sakai-Sakasai - Medical Hypotheses, 2024 - Elsevier
The habitual overconsumption of sugars has been implicated in the onset and/or
development of lifestyle-related diseases (LSRD). Advanced glycation end-products (AGEs) …
development of lifestyle-related diseases (LSRD). Advanced glycation end-products (AGEs) …
Differential impact of glucose levels and advanced glycation end-products on tubular cell viability and pro-inflammatory/profibrotic functions
B Franko, J Brault, T Jouve, S Beaumel… - Biochemical and …, 2014 - Elsevier
High glucose (HG) or synthetic advanced glycation end-products (AGE) conditions are
generally used to mimic diabetes in cellular models. Both models have shown an increase …
generally used to mimic diabetes in cellular models. Both models have shown an increase …
Cytotoxicity of advanced glycation endproducts in human micro-and astroglial cell lines depends on the degree of protein glycation
K Bigl, F Gaunitz, A Schmitt, S Rothemund… - Journal of Neural …, 2008 - Springer
Advanced glycation endproducts (AGEs) arise from the reaction of sugars with side chains
and the N-terminus of proteins and are thought to be involved in the pathogenesis of several …
and the N-terminus of proteins and are thought to be involved in the pathogenesis of several …
Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic β-cells
Advanced glycation endproducts (AGEs) and the receptor for AGEs (RAGE) have been
linked to the pathogenesis of diabetic complications, such as retinopathy, neuropathy, and …
linked to the pathogenesis of diabetic complications, such as retinopathy, neuropathy, and …
Advanced glycation endproduct induces ROS accumulation, apoptosis, MAP kinase activation and nuclear O-GlcNAcylation in human cardiac myocytes
SY Li, VK Sigmon, SA Babcock, J Ren - Life Sciences, 2007 - Elsevier
Accumulation of advanced glycation endproduct (AGE) has been implicated in the
pathogenesis of diabetic complications. However, the precise role and mechanism behind …
pathogenesis of diabetic complications. However, the precise role and mechanism behind …