Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding
and degradation is a central task of cells and tissues. The gradual decline of the capacity of …

While neurovascular diseases such as ischemic and hemorrhagic stroke are the leading
causes of disability in the world, the repertoire of therapeutic interventions has remained …

Simple Summary We used genetically modified mice overexpressing the cytokine
transforming growth factor beta 1 (TGF mice) that capture several aspects of the …

The human cerebrovascular system is responsible for regulating demand-dependent
perfusion and maintaining the blood-brain barrier (BBB). In addition, defects in the human …

Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

The cerebral vasculature ensures proper cerebral function by transporting oxygen, nutrients,
and other substances to the brain. Distribution of oxygenated blood throughout the …

The blood–brain barrier (BBB) regulates the passage of endogenous and exogenous
compounds and thus contributes to the brain homeostasis with the help of well-known …

Ischemic stroke is the most common type of stroke. Despite the fact that there have been
extensive efforts for establishing accurate diagnose and efficient therapy, ischemic stroke …

Abstract Background/Aims: Cerebral small vessel disease (SVD) is characterized by
periventricular white matter (WM) changes and can lead to vascular dementia, the second …

Cerebrovascular dysfunction and cerebral amyloid angiopathy (CAA) are hallmark features
of Alzheimer's disease (AD). Molecular damage to cerebrovessels in AD may result in …