Proteins are ordered useful cellular entities, required for normal health and organism's
survival. The proteome is the absolute set of cellular expressed proteins, which regulates a …

The structural integrity of cerebral vessels is compromised during ageing. Abnormal amyloid
(Aβ) deposition in the vasculature can accelerate age-related pathologies. The …

Maintaining proteostasis is essential for the CNS to function properly and to afford
appropriate stress responses, as it is for other organs. The nerve tissues' high demand for …

Recent advances within the field of proteomics, including both upstream and downstream
protocols, have fuelled a transition from simple protein identification to functional analysis. A …

Aims Amyloid beta (Aβ) accumulation in the walls of leptomeningeal arteries as cerebral
amyloid angiopathy (CAA) is a major feature of Alzheimer's disease. In this study, we used …

Stroke is the third leading cause of death in the United States with high rates of morbidity
among survivors. The search to fill the unequivocal need for new therapeutic approaches …

Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous
condition, arising from diverse microvascular mechanisms. These lead to chronic …

Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …

Preterm infants born before 29 gestation weeks incur major risk of subependymal/
intracerebral/intraventricular hemorrhage. In mice, neonate brain endothelial cells are more …

Alzheimer's disease (AD) is the principal cause of dementia in the elderly; however, its
prevalence is increasing due to the fact that current pharmaceuticals used to manage the …