Stroke is one of the most common causes of death worldwide and a major cause of acquired
disability in adults. Despite advances in research during the last decade, prevention and …

The arteriosclerosis-dependent alteration of brain perfusion is one of the major determinants
in small vessel disease, since small vessels have a pivotal role in the brain's autoregulation …

In 1927, the great Danish physicist Niels Bohr proposed that some natural phenomena can
only be completely understood by combining two or more experimental approaches that …

Proteins as a product from genetic information execute and determine how development,
growth, aging and disease factors are orchestrated within the lifetime of an organism …

Biomarker discovery is an application of major importance in today's proteomic research.
There is an urgent need for suitable biomarkers to improve diagnostic tools and treatment in …

The blood− brain barrier (BBB) is formed by endothelial cells of cerebral microvessels
sealed by tight junctions. Ischemic brain injury is known to initiate a series of biochemical …

INTRODUCTION Cerebrovascular dysfunction is a pathological hallmark of Alzheimer's
disease (AD). Nevertheless, detecting cerebrovascular changes within bulk tissues has …

Novel therapies and biomarkers are needed for the treatment of acute ischemic stroke (AIS).
This study aimed to provide comprehensive insights into the dynamic proteome changes …

Protein–protein interaction networks and signaling complexes are essential for normal brain
function and are often dysregulated in neurological disorders. Nevertheless, unraveling …

Matrix metalloproteinases (MMPs) mediate tissue injury during acute stroke. Clinical data
show that elevated MMPs in plasma of stroke patients may correlate with outcomes …