Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of
mortality and long-term injury. The prediction and early diagnosis of IS are therefore crucial …

Assessing protein changes in the cerebral vasculature of brain disorders may increase our
understanding of disease pathogenesis and facilitate diagnostic and therapeutic …

The enormous complexity of the central nervous system has impeded its systemic
exploration for decades but powerful" omic" technologies are now pushing forward the …

The cerebral vasculature, with its extensive network of arteries, veins, capillaries, and
perivascular compartments, constitutes a substantial component of the brain and provides …

Background A recent proteomics study of multiple sclerosis (MS) lesion-specific proteome
profiling clearly revealed a pivotal role of coagulation cascade proteins in chronic active …

Cardiovascular diseases constitute the largest of death in developed countries, being
atherosclerosis the major contributor. Atherosclerosis is a process of chronic inflammation …

Brain ischemia induced by cardiac arrest or ischemic stroke is a severe form of metabolic
stress that substantially disrupts cellular homeostasis, especially protein homeostasis …

Cerebral small vessel diseases (CSVDs) are prominent contributors to vascular cognitive
impairment and dementia and can arise from a range of etiologies. Cerebral amyloid …

Neurodegenerative diseases are a major health concern worldwide. Diseases such as
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

Small vessel disease (SVD) is a highly prevalent disorder of the brain's microvessels and a
common cause of dementia as well as ischaemic and haemorrhagic strokes. Though much …