Analysis of protein expression and abundance provides a possibility to extend the current
knowledge on disease‐associated processes and pathways. The human brain is a complex …

A new technique is sweeping the world, and changing the course of human work and life. It
is impacting upon models, methods and the development of medical research. In the …

Mechanisms underlying neural stem cell proliferation, differentiation and maturation play a
critical role in the formation and wiring of neuronal connections. This process involves the …

The pathophysiology underlying various manifestations of cerebral small vessel disease
(cSVD) remains obscure. Using cerebrospinal fluid proximity extension assays and co …

Cerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic
and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its …

Proteomics has revealed itself as a powerful tool in the identification and determination of
proteins and their biological significance. More recently, several groups have taken …

Proteomics is a field of study directed toward providing a comprehensive view of the
characteristics and activity of every cellular protein. Rapid innovations in the core …

The continuing improvement and refinement of proteomic and bioinformatic tools has made
it possible to obtain increasing amounts of structural and functional information about …

Small vessel disease (SVD) is one of the most frequent pathological conditions which lead
to dementia. Biochemical and neuroimaging might help correctly identify the clinical …

Dementia, a progressive and irreversible cognitive deterioration typically associated with
aging, has recently been recognized as one of the major health challenges of our century …