Cerebral small vessel diseases (CSVDs) are among the most common age-related
pathologies of the brain. Arteriolosclerosis and cerebral amyloid angiopathy (CAA) are the …

Cerebral small-vessel disease (SVD) is characterized by periventricular white matter (WM)
changes and general brain atrophy. SVD is prevalent in elderly individuals and is frequently …

Advances in technology have equipped the field of neuroproteomics with refined tools for
the study of the expression, interaction and function of proteins in the nervous system. In …

Cardiovascular diseases are leading causes of morbidity and mortality in developed
countries. Despite modern advances in science and medicine, our understanding of the …

Stroke is one of the main causes of mortality and long-term disability worldwide. The
pathophysiological mechanisms underlying this disease are not well understood …

Cardiovascular diseases constitute the largest of death in the Western world. Various
stressors, including elevated blood pressure, smoking, diabetes, and hypercholesterolemia …

Alzheimer's disease (AD) is the most common form of dementia found in all human
populations worldwide, while vascular dementia (VaD) is the second most common form of …

Ischemic stroke is caused by blood clot formation and consequent vessel blockage.
Proteomic approaches provide a cost-effective alternative to current diagnostic methods …

Publisher Summary This chapter surveys the profiles of cerebral blood flow and tissue injury
during reperfusion, examines the pathophysiology of free radicals and inflammation, and …

1216 Stroke April 2014 mechanisms, and vascular reactivity to the partial pressure of arterial
CO2. 7, 10 Local changes in cellular activity (mostly neurons and glia) modulate CBF above …