The cerebrovascular-specific molecular mechanism in Alzheimer's disease (AD) was
investigated by employing comprehensive and accurate quantitative proteomics. Highly …

Common cerebral small vessel disease (cSVD) abnormalities are a common
neuroradiological finding, especially in the elderly. They are associated with a wide clinical …

Cerebrovascular insufficiency appears years prior to clinical symptoms in Alzheimer's
disease. The soluble, highly toxic amyloid-β species, generated from the amyloidogenic …

Changes in protein structure and function, alteration in protein-protein interaction, and
significant difference in protein concentration inside the body could play an important role in …

Vascular disorders, and in particular atherothrombosis, are currently a leading cause of
morbidity and mortality in Western societies. Proteomics research into these disorders has …

The association between cerebral small vessel disease (SVD)–in the form of white matter
lesions, infarctions, and hemorrhages–with vascular cognitive impairment (VCI), has mostly …

The blood–brain barrier (BBB) is essential for cerebral homeostasis and controls the
selective passage of molecules traveling in and out of the brain. Despite the crucial role of …

The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

The themed issue, initiated by the Vascular Experimental Theme of the Dementia Platform
UK (DPUK), will include critical reviews on several key topics from experts in the field–these …

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment
and dementia with limited therapeutic interventions. There is a critical need to provide …