The enormous complexity of the central nervous system has impeded its systemic
exploration for decades but powerful" omic" technologies are now pushing forward the …

An extensive guide on practicable and significant quantitative proteomic approaches in
neuroscience research is important not only because of the existing overwhelming …

Proteomics is a field of study directed toward providing a comprehensive view of the
characteristics and activity of every cellular protein. Rapid innovations in the core …

Protein–protein interaction networks and signaling complexes are essential for normal brain
function and are often dysregulated in neurological disorders. Nevertheless, unraveling …

The human brain represents one of the most complex biological structures with significant
spatiotemporal molecular plasticity occurring through early development, learning, aging …

Advances in technology have equipped the field of neuroproteomics with refined tools for
the study of the expression, interaction and function of proteins in the nervous system. In …

In this review we discuss the merits and drawbacks with the use of proteomic and
peptidomic strategies for identification of proteins and peptides in their multidimensional …

The immense intercellular and intracellular heterogeneity of the CNS presents major
challenges for high-throughput omic analyses. Transcriptional, translational and post …

Proteomics is complementary to genomic approaches anchored in DNA and RNA. Global
characterization of proteins is providing new insights into general biological structures as …

The brain is unquestionably the most fascinating organ. Despite tremendous progress,
current knowledge falls short of being able to explain its function. An emerging approach …