Machine learning analysis of the cerebrovascular thrombi proteome in human ischemic stroke: an exploratory study

C Dargazanli, E Zub, J Deverdun… - Frontiers in …, 2020 - frontiersin.org
Objective: Mechanical retrieval of thrombotic material from acute ischemic stroke patients
provides a unique entry point for translational research investigations. Here, we resolved the …

Mass spectrometry-based proteomic profiling of thrombotic material obtained by endovascular thrombectomy in patients with ischemic stroke

R Muñoz, E Santamaría, I Rubio, K Ausín… - International journal of …, 2018 - mdpi.com
Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a
valuable source of biological information. In this study, we have developed a clinical …

The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its etiology, severity, and prognosis

C Lopez-Pedrera, R Oteros, A Ibáñez-Costa… - Journal of Thrombosis …, 2023 - Elsevier
Background Nowadays little is known about the molecular profile of the occluding thrombus
of patients with ischemic stroke. Objectives To analyze the proteomic profile of thrombi in …

Potential biomarkers of acute ischemic stroke etiology revealed by mass spectrometry-based proteomic characterization of formalin-fixed paraffin-embedded blood …

R Rossi, OM Mereuta, M Barbachan e Silva… - Frontiers in …, 2022 - frontiersin.org
Background and Aims Besides the crucial role in the treatment of acute ischemic stroke
(AIS), mechanical thrombectomy represents a unique opportunity for researchers to study …

Plasma protein alterations during human large vessel stroke: A controlled comparison study

HS Hazelwood, JA Frank, B Maglinger… - Neurochemistry …, 2022 - Elsevier
Background Stroke is a major cause of death and disability in the United States. Mechanical
thrombectomy (MT) and tissue plasminogen activator are the current treatments for ischemic …

Advancing Stroke Research on Cerebral Thrombi with Omic Technologies

G Costamagna, S Bonato, S Corti… - International Journal of …, 2023 - mdpi.com
Cerebrovascular diseases represent a leading cause of disability, morbidity, and death
worldwide. In the last decade, the advances in endovascular procedures have not only …

Proteomic changes in intracranial blood during human ischemic stroke

B Maglinger, JA Frank, CJ McLouth, AL Trout… - Journal of …, 2021 - jnis.bmj.com
Background Since 2015, mechanical thrombectomy has been the standard treatment for
emergent large vessel occlusion ischemic stroke. Objective To investigate, using the …

Peptide composition of stroke causing emboli correlate with serum markers of atherosclerosis and inflammation

NM Rao, J Capri, W Cohn, M Abdaljaleel… - Frontiers in …, 2017 - frontiersin.org
Introduction The specific protein composition of stroke-causing emboli is unknown. Because
ischemic stroke has a varied etiology, it is possible that the composition of the thrombus from …

Proteomics-based identification of diagnostic biomarkers related to risk factors and pathogenesis of ischemic stroke

J Lee, A Park, S Mun, HJ Kim, H Son, H Choi, D Kim… - Diagnostics, 2020 - mdpi.com
Ischemic stroke is caused by blood clot formation and consequent vessel blockage.
Proteomic approaches provide a cost-effective alternative to current diagnostic methods …

Proteomics reveals plasma biomarkers for ischemic stroke related to the coagulation cascade

J Lee, S Mun, A Park, D Kim, YJ Lee, HJ Kim… - Journal of Molecular …, 2020 - Springer
Stroke has a high incidence rate and often leads to permanent disability, particularly if it is
not treated promptly. However, no blood biomarkers for early diagnosis are available to …