Comprehensive intra-individual genomic and transcriptional heterogeneity: Evidence-based Colorectal Cancer Precision Medicine

ID Kyrochristos, DH Roukos - Cancer treatment reviews, 2019 - Elsevier
Despite advances in translating conventional research into multi-modal treatment for
colorectal cancer (CRC), therapeutic resistance and relapse remain unresolved in advanced …

Bulk and single-cell next-generation sequencing: individualizing treatment for colorectal cancer

ID Kyrochristos, DE Ziogas, A Goussia, GK Glantzounis… - Cancers, 2019 - mdpi.com
The increasing incidence combined with constant rates of early diagnosis and mortality of
colorectal cancer (CRC) over the past decade worldwide, as well as minor overall survival …

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

NS Kiran, C Yashaswini, R Maheshwari… - ACS Pharmacology & …, 2024 - ACS Publications
Precision medicine is transforming colorectal cancer treatment through the integration of
advanced technologies and biomarkers, enhancing personalized and effective disease …

From tumour heterogeneity to advances in precision treatment of colorectal cancer

CJA Punt, M Koopman, L Vermeulen - Nature reviews Clinical oncology, 2017 - nature.com
In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …

[HTML][HTML] Colorectal cancer genomics and designing rational trials

S Mondaca, R Yaeger - Annals of Translational Medicine, 2018 - ncbi.nlm.nih.gov
The widespread use of next generation sequencing (NGS) has led to a refined
understanding of the genomics of colorectal cancer (CRC). However, progress in the use of …

[HTML][HTML] Genomic diversity of colorectal cancer: Changing landscape and emerging targets

DH Ahn, KK Ciombor, S Mikhail… - World journal of …, 2016 - ncbi.nlm.nih.gov
Improvements in screening and preventive measures have led to an increased detection of
early stage colorectal cancers (CRC) where patients undergo treatment with a curative …

Clinical multigene panel sequencing identifies distinct mutational association patterns in metastatic colorectal cancer

F Belardinilli, C Capalbo, U Malapelle, P Pisapia… - Frontiers in …, 2020 - frontiersin.org
Extensive molecular characterization of human colorectal cancer (CRC) via Next Generation
Sequencing (NGS) indicated that genetic or epigenetic dysregulation of a relevant, but …

Colorectal cancer: Genetic alterations, novel biomarkers, current therapeutic strategies and clinical trails

M Housini, B Dariya, N Ahmed, A Stevens, H Fiadjoe… - Gene, 2023 - Elsevier
Colorectal cancer (CRC) is the third most commonly detected cancer with a serious global
health issue. The rates for incidence and mortality for CRC are alarming, especially since …

Integrated approaches for precision oncology in colorectal cancer: The more you know, the better

P Andrei, P Battuello, G Grasso, E Rovera… - Seminars in cancer …, 2022 - Elsevier
Colorectal cancer (CRC) is one of the most common human malignancies accounting for
approximately 10% of worldwide cancer incidence and mortality. While early-stage CRC is …

Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways

H Postwala, Y Shah, PS Parekh, MR Chorawala - Medical Oncology, 2023 - Springer
Colorectal cancer (CRC) is a complex disease characterized by genetic and epigenetic
alterations, playing a crucial role in its development and progression. This review aims to …