Simple Summary Metastatic colorectal cancer is a complex, prevalent, and life-threatening
disease influenced by various factors that affect its progression, evolution, and treatment …

Critical driver genomic events in colorectal cancer have been shown to affect the response
to targeted agents that were initially developed under the'one gene, one drug'paradigm of …

Approximately 20 drugs have been shown to be effective for the treatment of colorectal
cancer (CRC). These drugs are from several classes of agents and include cytotoxic drugs …

Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Simple Summary Cancer affects millions of individuals every year, with colorectal cancer
being among the most common. There is an increased need to identify new biomarkers that …

Highlights•Cancer genome evolution and tumor heterogeneity explain therapeutic
resistance, relapse and death.•Standard single biopsy NGS and novel NGS applications …

Colorectal cancer (CRC) is a genetically heterogeneous disease with its pathogenesis often
driven by varying genetic or epigenetic alterations. This has led to a substantial number of …

Background Colorectal cancer (CRC) is the third most common cancer diagnosed
worldwide and continues to be a major healthcare concern. Molecular heterogeneity of CRC …

Novel targeted therapies for metastatic colorectal cancer are needed to personalize
treatments by guiding specific biomarkers selected on the genetic profile of patients. RAS …

Colorectal cancer (CRC), a leading cause of cancer-related mortalities globally, results from
the accumulation of multiple genetic and epigenetic alterations in the normal colonic and …