Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

Z Li, J Chen, H Yu, L He, Y Xu, D Zhang, Q Yi, C Li… - Nature …, 2017 - nature.com
We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Comparative genetic architectures of schizophrenia in East Asian and European populations

M Lam, CY Chen, Z Li, AR Martin, J Bryois, X Ma… - Nature …, 2019 - nature.com
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11. 2

WH Yue, HF Wang, LD Sun, FL Tang, ZH Liu… - Nature …, 2011 - nature.com
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective

CA Dennison, SE Legge, AF Pardinas… - Schizophrenia research, 2020 - Elsevier
Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …

Genome-wide association studies of schizophrenia: does bigger lead to better results?

SE Bergen, TL Petryshen - Current opinion in psychiatry, 2012 - journals.lww.com
Identifying the genetic underpinnings of complex diseases offers insight into the etiological
mechanisms leading to manifestation of the disease. New and more effective treatments for …

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

SH Lee, TR DeCandia, S Ripke, J Yang… - Nature …, 2012 - nature.com
Schizophrenia is a complex disorder caused by both genetic and environmental factors.
Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the …

Boosting the power of schizophrenia genetics by leveraging new statistical tools

OA Andreassen, WK Thompson… - Schizophrenia …, 2014 - academic.oup.com
Genome-wide association studies (GWAS) have identified a large number of gene variants
associated with schizophrenia, but these variants explain only a small portion of the …

Common variants on 2p16. 1, 6p22. 1 and 10q24. 32 are associated with schizophrenia in Han Chinese population

H Yu, H Yan, J Li, Z Li, X Zhang, Y Ma, L Mei… - Molecular …, 2017 - nature.com
Many schizophrenia susceptibility loci have been identified through genome-wide
association studies (GWASs) in European populations. However, until recently …

Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia

MJ Owen, N Craddock… - Archives of general …, 2010 - jamanetwork.com
This article reviews recent genome-wide association studies (GWAS) of schizophrenia and
considers future research directions. Until recently, genome-wide scans for dis-ease risk …