Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers

K Liu, C Xu, J Liu - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Understanding the effects of surface density and distribution of ligands on their recognition
and binding is critical for the regulation of cellular behaviors. However, the correlation of …

Tunable multivalent aptamer-based DNA nanostructures to regulate multiheteroreceptor-mediated tumor recognition

X Hu, H Chi, X Fu, J Chen, L Dong… - Journal of the …, 2024 - ACS Publications
Precise mapping and regulation of cell surface receptors hold immense significance in
disease treatment, such as cancer, infection, and neurodisorders, but also face enormous …

Site-specific anchoring aptamer C2NP on DNA origami nanostructures for cancer treatment

P Sun, N Zhang, Y Tang, Y Yang, J Zhou, Y Zhao - RSC advances, 2018 - pubs.rsc.org
Because of the remarkable features, including biocompatibility and biodegradability, DNA
origami nanostructures have drawn much attention as ideal carriers for drug delivery …

Multivalent aptamer-modified DNA origami as drug delivery system for targeted cancer therapy

M Cao, Y Sun, M Xiao, L Li, X Liu, H Jin… - Chemical Research in …, 2020 - Springer
In spite of great development in nanoparticle-based drug delivery systems (DDSs) for
improved therapeutic efficacy, it remains challenging for effective delivery of …

Visualization of the cellular uptake and trafficking of DNA origami nanostructures in cancer cells

P Wang, MA Rahman, Z Zhao, K Weiss… - Journal of the …, 2018 - ACS Publications
DNA origami is a promising molecular delivery system for a variety of therapeutic
applications including cancer therapy, given its capability to fabricate homogeneous …

Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery

M Safarkhani, S Ahmadi, H Ipakchi, MR Saeb… - Advanced …, 2024 - Wiley Online Library
DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not
found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating …

DNA aptamers for the functionalisation of DNA origami nanostructures

Y Sakai, MS Islam, M Adamiak, SCC Shiu, JA Tanner… - Genes, 2018 - mdpi.com
DNA origami has emerged in recent years as a powerful technique for designing and
building 2D and 3D nanostructures. While the breadth of structures that have been produced …

DNA origami nanostructures for controlled therapeutic drug delivery

J Weiden, MMC Bastings - Current Opinion in Colloid & Interface Science, 2021 - Elsevier
DNA nanostructures are emerging as a versatile platform for controlled drug delivery as a
result of recent progress in production yield and strategies to obtain prolonged stability in …

Modular DNA-origami-based nanoarrays enhance cell binding affinity through the “lock-and-key” interaction

M Mao, Z Lin, L Chen, Z Zou, J Zhang… - Journal of the …, 2023 - ACS Publications
Surface proteins of cells are generally recognized through receptor–ligand interactions
(RLIs) in disease diagnosis, but their nonuniform spatial distribution and higher-order …

DNA origami as a carrier for circumvention of drug resistance

Q Jiang, C Song, J Nangreave, X Liu… - Journal of the …, 2012 - ACS Publications
Although a multitude of promising anti-cancer drugs have been developed over the past 50
years, effective delivery of the drugs to diseased cells remains a challenge. Recently …